To develop effective means to treat cancer, it would be desirable to identify essential growth drivers that cancer cells are completely addicted to. Here we discovered amino acid substitutions in RAC1 and RAC2 small GTP-binding proteins in various human cancer, which confer potent transforming ability. Since suppression of such RAC1/2 mutants leads to cancer cell death, oncogenic RAC1/2 proteins are suitable targets to raise novel reagents to treat cancers positive for these mutations.
JST Research Acceleration Program
Research Theme : “Identification of novel oncogenes in human cancer”
Published on 4 February 2013 as Online Publication in “Proceedings of the National Academy of Sciences of USA”.
Masahito Kawazu, Toshihide Ueno, Kenji Kontani, Yoshitaka Ogita, Mizuo Ando, Kazutaka Fukumura,Azusa Yamato, Manabu Soda, Kengo Takeuchi, Yoshio Miki, Hiroyuki Yamaguchi, Takahiko Yasuda,Tomoki Naoe, Yoshihiro Yamashita, Toshiaki Katada, Young Lim Choi, and Hiroyuki Mano
“Transforming mutations of RAC guanosine triphosphatases in human cancers”
Hiroyuki Mano, M.D.,Ph.D.
Professor, Jichi Medical University,
Project Professor, University of Tokyo,
Department of Innovation Research,
Japan Science and Technology Agency