Home > Press Releases
JST Press Release

November 21, 2014
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Identification of host proteins important for influenza virus replication for antiviral drug development

Genome-wide screens are increasingly used to identify host factors that could be targeted for drug development. The authors identified over 1000 host factors that co-immunoprecipitated with influenza viral proteins. Mechanistic studies on 91 of these factors identified the affected step(s) in viral replication. Further analyses validated potential targets for antiviral drugs.

Researcher Information

JST Strategic Basic Research Programs
Discovery and development of next-generation vaccines and antivirals against influenza
ERATO Kawaoka Infection-induced Host Responses

Journal Information

Tokiko Watanabe, Eiryo Kawakami, Jason E. Shoemaker, Tiago J. S. Lopes, Yukiko Matsuoka, Yuriko Tomita, Hiroko Kozuka-Hata, Takeo Gorai, Tomoko Kuwahara, Eiji Takeda, Atsushi Nagata, Ryo Takano, Maki Kiso, Makoto Yamashita, Yuko Sakai-Tagawa, Hiroaki Katsura, Naoki Nonaka, Hiroko Fujii, Ken Fujii, Yukihiko Sugita, Takeshi Noda, Hideo Goto, Satoshi Fukuyama, Shinji Watanabe, Gabriele Neumann, Masaaki Oyama, Hiroaki Kitano, and Yoshihiro Kawaoka. “Influenza virus-host interactome screen as a platform for antiviral drug development ”. Cell Host & Microbe, Published online 20 November 2014, doi: 10.1016/j.chom.2014.11.002.

Contact

[About Research]
Yoshihiro Kawaoka, D.V.M., Ph.D.
Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639
Tel:+81-(0)3-5449-5310 Fax:+81-(0)3-5449-5408
E-mail:
URL: http://www.jst.go.jp/erato/kawaoka/index.html

[About Program]
Takeshi Ohyama
Department of Research Project, JST
Ks Goban-cho 7, Goban-cho, Chiyoda-ku, Tokyo102-0076
Tel:+81-(0)3-3512-3528 Fax:+81-(0)3-3222-2068
E-mail:

Japanese


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/