Genome-wide screens are increasingly used to identify host factors that could be targeted for drug development. The authors identified over 1000 host factors that co-immunoprecipitated with influenza viral proteins. Mechanistic studies on 91 of these factors identified the affected step(s) in viral replication. Further analyses validated potential targets for antiviral drugs.
JST Strategic Basic Research Programs
Discovery and development of next-generation vaccines and antivirals against influenza
ERATO Kawaoka Infection-induced Host Responses
Tokiko Watanabe, Eiryo Kawakami, Jason E. Shoemaker, Tiago J. S. Lopes, Yukiko Matsuoka, Yuriko Tomita, Hiroko Kozuka-Hata, Takeo Gorai, Tomoko Kuwahara, Eiji Takeda, Atsushi Nagata, Ryo Takano, Maki Kiso, Makoto Yamashita, Yuko Sakai-Tagawa, Hiroaki Katsura, Naoki Nonaka, Hiroko Fujii, Ken Fujii, Yukihiko Sugita, Takeshi Noda, Hideo Goto, Satoshi Fukuyama, Shinji Watanabe, Gabriele Neumann, Masaaki Oyama, Hiroaki Kitano, and Yoshihiro Kawaoka. “Influenza virus-host interactome screen as a platform for antiviral drug development ”. Cell Host & Microbe, Published online 20 November 2014, doi: 10.1016/j.chom.2014.11.002.
Yoshihiro Kawaoka, D.V.M., Ph.D.
Division of Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639
Department of Research Project, JST
K’s Goban-cho 7, Goban-cho, Chiyoda-ku, Tokyo102-0076