| Project Title | Japanese Researcher | Position and Institution | Abstract of Research Project | |
|---|---|---|---|---|
| Indian Researcher | ||||
| Identification of biomarkers for infection-induced reactive arthritis based on the inflammation amplifier | Masaaki Murakami | Professor, Institute for Genetic Medicine, Hokkaido University |
Bacteria-induced reactive arthritis (ReA) is a major health problem causing acute and chronic arthritis following bacterial infections in adolescents and young adults. Since enteric infection burden is high in India, post enteric arthritis is expected to be high. There are challenges in treating this disease, as there are no diagnostic tests or diagnostic biomarkers for prognostication. This Indo-Japanese collaboration will develop experimental models to study the pathogenesis of Salmonella induced ReA and then validate the results of the experimental models in actual patients. This collaboration will also help to develop a key liaison between an advanced center in India and an established and meritorious Japanese group to do translational research. | |
| Ramnath Misra | Dean, Professor and Head, Department of Clinical Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences |
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| Improvement of the accuracy for differential diagnosis against viral infection -DENV, CHIKV, and FluV- by spreading of high quality RDT in India | Takeshi Kurosu | Assistant Professor, Research Institute for Microbial Diseases, Osaka University |
This project aims to develop simple, rapid diagnosis test (RDT) kits for dengue, chikungunya and influenza viruses and to emphasise the importance of early diagnosis. Patients with these diseases show similar symptoms at early stages, but require very different treatments. Thus, it is very important to diagnose infections at an early stage. The Japanese side will develop the RDTs, while the Indian side will evaluate the effectiveness of the RDTs and perform epidemiological studies. As a result of this collaboration, we expect that the application of RDTs will spread throughout South Asian countries in the near future, yielding important epidemiological information in infectious diseases and giving us an advantage in the prevention of epidemics. | |
| Rajni Gaind *Indian PI |
Consultant, Department of Microbiology, Vardhman Mahavir Medical College (VMMC) |
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| Sujatha Sunil *Indian co-PI |
Research Scientist, International Centre for Genetic Engineering and Biotechnology |
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| Role of TLRs in patients with severe complicated malaria due to Plasmodium vivax and the development of diagnostic method for predicting the severity | Fumie Kobayashi | Professor, Department of Infectious Diseases, School of Medicine, Kyorin University |
This project aims to elucidate the roles of host factors such as TLRs in severe vivax malaria leading to the development of early diagnosis and prediction of severity. Specifically, the Indian researchers will investigate the roles of host factors in patients with severe vivax malaria. On the basis of knowledge obtained from the Indian side, Japanese researchers will establish mouse malaria models for investigating severe malaria, and examine the host factors involved in severity. This international collaborative research will contribute to our understanding of severity-related factors in vivax malaria infection and will develop novel diagnostic and therapeutic strategies for this disease. | |
| Rakesh Sehgal | Professor and Head, Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research (PGIMER) | |||