Neovascularization from existing blood vessels, which is called angiogenesis, is essential for tissue growth and repair. Proangiogenic therapies for brain stroke can potentially prevent excess neuron death and improve functional recovery. The laminin-sponge with affinity-immobilized vascular endothelial growth factor, which is an angiogenic growth factor, is reported. The angiogenic activity of this sponge in vivo in a mouse stroke model is demonstrated.
Research Area “Molecular technology and creation of new functions”
Research Theme “Development of brain regeneration device using artificial protein activated under hypoxia”
Oshikawa M, Okada K, Kaneko N, Sawamoto K, and Ajioka I. “Affinity-Immobilization of VEGF on Laminin Porous Sponge Enhances Angiogenesis in the Ischemic Brain”. Advanced Healthcare Materials, Published online May 10, 2017, doi: 10.1002/adhm.201700183
Itsuki Ajioka, Ph.D.
Associate professor, Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU)
Green Innovation Group, Department of Innovation Research, JST