Home > Press Releases
JST Press Release

April 6, 2017
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Breast cancer remotely rewires hepatic circadian transcriptome

A possible target to ameliorate cancer's adverse effects on host

Dr. Kawaoka's group shows that murine breast cancer remotely reprograms hepatic circadian transcriptome. They, with the aid of a mouse model of breast cancer and transcriptome analysis, identified a number of abnormal daily expression patterns of oscillating genes in the liver of cancer-bearing mouse. Some genes exhibited a marked pattern of disruption, "day-night reversal." These rewired gene expression patterns led the team to find various cancer-induced physiological abnormalities in the liver such as increased oxidative stress and hepatic polyploidization. The study will be an important basis for devising a therapy that ameliorates cancer's adverse effects on host.

Program Information

Sato Live Bio-Forecasting Project

Journal Information

Hiroaki Hojo, Sora Enya, Miki Arai, Yutaka Suzuki, Takashi Nojiri, Kenji Kangawa, Shinsuke Koyama and Shinpei Kawaoka. “Remote reprogramming of hepatic circadian transcriptome by breast cancer”, Oncotarget, published online April 6, 2017, doi: 10.18632/oncotarget.16699


[About Research]
Shinpei Kawaoka, Ph.D.
Group Leader, ERATO Sato Live Bio-Forecasting Project
Senior Researcher, The Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications
Research Institute International

[About Program]
Takeshi Ohyama
Department of Research Project, JST


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/