Dr. Kawaoka's group shows that murine breast cancer remotely reprograms hepatic circadian transcriptome. They, with the aid of a mouse model of breast cancer and transcriptome analysis, identified a number of abnormal daily expression patterns of oscillating genes in the liver of cancer-bearing mouse. Some genes exhibited a marked pattern of disruption, "day-night reversal." These rewired gene expression patterns led the team to find various cancer-induced physiological abnormalities in the liver such as increased oxidative stress and hepatic polyploidization. The study will be an important basis for devising a therapy that ameliorates cancer's adverse effects on host.
Sato Live Bio-Forecasting Project
Hiroaki Hojo, Sora Enya, Miki Arai, Yutaka Suzuki, Takashi Nojiri, Kenji Kangawa, Shinsuke Koyama and Shinpei Kawaoka. “Remote reprogramming of hepatic circadian transcriptome by breast cancer”, Oncotarget, published online April 6, 2017, doi: 10.18632/oncotarget.16699
Shinpei Kawaoka, Ph.D.
Group Leader, ERATO Sato Live Bio-Forecasting Project
Senior Researcher, The Thomas N. Sato BioMEC-X Laboratories, Advanced Telecommunications
Research Institute International
Department of Research Project, JST