Surface-specific recognition and size-regulation of aminopeptidase I aggregates by a receptor protein Atg19 has been established. This result can be a basis for elucidating the mechanism of selective autophagy of harmful protein aggregates, which would facilitate the development of preventive and curative medicines for neurodegenerative diseases.
Research Area “Structural Life Science and Advanced Core Technologies for Innovative Life Science Research”
Research Theme “Structural life science for unveiling membrane dynamics during autophagy”
Akinori Yamasaki, Yasunori Watanabe, Wakana Adachi, Kuninori Suzuki, Kazuaki Matoba, Hiromi Kirisako, Hiroyuki Kumeta, Hitoshi Nakatogawa, Yoshinori Ohsumi, Fuyuhiko Inagaki and Nobuo N. Noda. “Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates”. Cell Reports, Published online 16 June 2016, doi: 10.1016/j.celrep.2016.05.066.
Nobuo N. Noda, Ph.D.
Chief Researcher, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation
Life Innovation Group, Department of Innovation Research, JST