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JST Press Release

June 17, 2016
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Molecular mechanism of recognition and sequestration of protein aggregates by selective autophagy

Surface-specific recognition and size-regulation of aminopeptidase I aggregates by a receptor protein Atg19 has been established. This result can be a basis for elucidating the mechanism of selective autophagy of harmful protein aggregates, which would facilitate the development of preventive and curative medicines for neurodegenerative diseases.

Program Information

Research Area “Structural Life Science and Advanced Core Technologies for Innovative Life Science Research”
Research Theme “Structural life science for unveiling membrane dynamics during autophagy”

Journal Information

Akinori Yamasaki, Yasunori Watanabe, Wakana Adachi, Kuninori Suzuki, Kazuaki Matoba, Hiromi Kirisako, Hiroyuki Kumeta, Hitoshi Nakatogawa, Yoshinori Ohsumi, Fuyuhiko Inagaki and Nobuo N. Noda. “Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates”. Cell Reports, Published online 16 June 2016, doi: 10.1016/j.celrep.2016.05.066.


[About Research]
Nobuo N. Noda, Ph.D.
Chief Researcher, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation
URL: http://www.bikaken.or.jp/english/index.php

[About Program]
Tetsu Kawaguchi
Life Innovation Group, Department of Innovation Research, JST


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/