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JST Press Release

August 11, 2015
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Discovery and molecular and biocatalytic properties of hydroxynitrile lyase from an invasive millipede Chamberlinius hualienensis

They found a new hydroxynitrile lyase (HNL) with the highest specific activity toward benzaldehyde and wide temperature and pH stabilities from a millipede. Since the HNL is highly enantioselective in the synthesis of various cyanohydrins, it is expected as the next generation biocatalyst for production of R-specific cyanohydrins.

Researcher Information

JST ERATO
ERATO Asano Active Enzyme Molecule Project

Journal Information

Mohammad Dadashipour, Yuko Ishida, Kazunori Yamamoto, and Yasuhisa Asano. “Discovery and molecular and biocatalytic properties of hydroxynitrile lyase from an invasive millipede, Chamberlinius hualienensis”. Proceedings of the National Academy of Sciences of the United States of America, vol. 112 no. 34, 2015, doi: 10.1073/pnas.1508311112.

Contact

[About Research]
Yasuhisa Asano, Ph.D.
Professor, Toyama Prefectural University
E-mail:

[About Program]
Hisao Mizuta
Department of Research Project, JST
Ks Goban-cho 7, Goban-cho, Chiyoda-ku, Tokyo 102-0076 Japan
Tel: +81-3-3512-3528 Fax: +81-3-3222-2068
E-mail:

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