- Depletion of CD169+ macrophages suppresses DSS-induced colitis in mice.
- Monocyte infiltration, but not neutrophils or eosinophils, was reduced in the absence of CD169+ macrophages.
- CCL8 is produced exclusively by CD169+ macrophages in the colon.
- Administration of anti-CCL8 antibody ameliorates the clinical symptoms of DSS-induced colitis.
Research Area “ Elucidation and control of the mechanisms underlying chronic inflammation”
Research Theme “ Development of Sentinel Cell-targeted Therapy for Inflammatory Bowel Diseases”
Authors: Kenichi Asano, Naomichi Takahashi, Mikiko Ushiki, Misa Monya, Fumiaki Aihara, Erika Kuboki, Shigetaka Moriyama, Mayumi Iida, Hiroshi Kitamura, Chun-Hong Qiu, Takashi Watanabe, and Masato Tanaka. “Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes”. Nature Communications, Published online 21 July 2015, doi: 10.1038/ncomms8802.
Kenichi Asano, M.D., Ph.D.
Associate Professor, Laboratory of Immune Regulation, School of Life Science, Tokyo University of Pharmacy and Life Sciences
Koji Matsuo, Tetsu Kawaguchi, and Shinichi Kato
Life Innovation Group, Department of Innovation Research, JST