LFA-1 is one of the major adhesion molecules involved in lymphocyte trafficking. In this study, we identified a mechanism by which the kinase Mst1 and Rab13 transport LFA-1 from the inside of lymphocyte to the leading edge where LFA-1 forms cluster to generate new adhesion points. Rab13–deficient lymphocytes showed impaired adhesion and migration, and Rab13–deficient mice showed smaller lymphoid tissues due to defective trafficking capacity of lymphocytes.
Research Area: “Etiological basics of and techniques for treatment of allergic and autoimmune diseases”
Research Theme: “Dysregulation of immune-cell trafficking signaling and development of autoimmunity”
Author: Akihiko Nishikimi, Sayaka Ishihara, Madoka Ozawa, Kan Etoh, Mitsunori Fukuda, Tatsuo Kinashi, and Koko Katagiri
Title: “Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking”
Science Signaling, Published online 29th July 2014
Koko Katagiri, Ph.D.
Professor, Department of Biosciences, School of Science, Kitasato University
Life Innovation Group, Department of Innovation Research, JST