It has been reported that diabetic conditions accelerate vascular senescence. We here show a crucial role for endothelial activation of p53, a critical factor that induces cellular senescence, in glucose homeostasis. Our results suggest that a detrimental vicious cycle may exist, in which vascular senescence induces metabolic abnormalities that in turn promote cardiovascular dysfunction. Inhibition of endothelial p53 activation could be a novel therapeutic target to block such a vicious circle in diabetic patients.
Research Area: “Elucidation and control of the mechanisms underlying chronic inflammation”
Research Theme: “Molecular analyses of the mechanisms of age-associated chronic inflammation by using long-lived or aging mouse models”
Author: Masataka Yokoyama, Sho Okada, Atsushi Nakagomi, Junji Moriya, Ippei Shimizu, Aika Nojima, Yohko Yoshida, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Marcus Fruttiger, Guillermina Lozano, Tohru Minamino
Title: “Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesit”
Cell Reports, Published Online: May 22, 2014
Tohru Minamino M.D., Ph.D.
Professor and Chairman, Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences
Takafumi Kawaguchi, Koji Matsuo, and Toshiyuki Shingo
Life Innovation Group, Department of Innovation Research, JST