It has been reported that diabetic conditions accelerate vascular senescence. We here show a crucial role for endothelial activation of p53, a critical factor that induces cellular senescence, in glucose homeostasis. Our results suggest that a detrimental vicious cycle may exist, in which vascular senescence induces metabolic abnormalities that in turn promote cardiovascular dysfunction. Inhibition of endothelial p53 activation could be a novel therapeutic target to block such a vicious circle in diabetic patients.
Researcher Information
JST PRESTO
Research Area: “Elucidation and control of the mechanisms underlying chronic inflammation”
Research Theme: “Molecular analyses of the mechanisms of age-associated chronic inflammation by using long-lived or aging mouse models”
Journal Information
Author: Masataka Yokoyama, Sho Okada, Atsushi Nakagomi, Junji Moriya, Ippei Shimizu, Aika Nojima, Yohko Yoshida, Harumi Ichimiya, Naomi Kamimura, Yoshio Kobayashi, Shigeo Ohta, Marcus Fruttiger, Guillermina Lozano, Tohru Minamino
Title: “Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesit”
Cell Reports, Published Online: May 22, 2014
doi: 10.1016/j.celrep.2014.04.046
Contact
[About Research]
Tohru Minamino M.D., Ph.D.
Professor and Chairman, Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences
E-mail: 
[About Program]
Takafumi Kawaguchi, Koji Matsuo, and Toshiyuki Shingo
Life Innovation Group, Department of Innovation Research, JST
E-mail: 