They found that a cobalt(III) catalyst in combination with an acetate ion works cooperatively and shows wider applicability than conventional rhodium(III) catalysts. This result is expected, and greatly contributes to an efficient, low-costing, and environmentally-friendly synthesis of medicines.
JST ACT-C (Advanced Catalytic Transformation Program for Carbon Utilization),
Research Area: “Creation of Advanced Catalytic Transformation for the Sustainable Manufacturing at Low Energy, Low Environmental Load”,
Research Theme: Development and Applications of Cooperative Catalysts towards Life Innovation
Hideya Ikemoto, Tatsuhiko Yoshino, Ken Sakata, Shigeki Matsunaga, and Motomu Kanai,
“Pyrroloindolone Synthesis via a Cp*CoIII-Catalyzed Redox-Neutral Directed C-H Alkenylation/Annulation Sequence”
Journal of the American Chemical Society, 2014, in press.
Shigeki Matsunaga Ph.D.
Laboratory Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences,
The University of Tokyo
Department of Research Project
Japan Science and Technology Agency (JST)