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JST Press Release

Nov. 15, 2013
Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666
URL http://www.jst.go.jp/EN/index.html

Discovery of a new braking system regulating the immune response

The research group has revealed that EZH2, which is known as a repressor of gene expression, acts on the immune system and controls excessive immune responses. They made gene maps of the place where EZH2 bound and clarified a mechanism underlying expression of immune-related genes mediated by EZH2.

Researcher Information

Research Area: “Creation of basic medical technologies to clarify and control the mechanisms underlying chronic inflammation”
Research Theme: “Regulation of chronic inflammation and the development of new strategies for treating airway inflammatory diseases”

Journal Information

Damon J. Tumes, Atsushi Onodera, Akane Suzuki, Kenta Shinoda, Yusuke Endo, Chiaki Iwamura, Hiroyuki Hosokawa, Haruhiko Koseki, Koji Tokoyoda, Yutaka Suzuki, Shinichiro Motohashi, Toshinori Nakayama.
“The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells” Immunity, 2013,
doi: 10.1016/j.immuni.2013.09.012


[About Research]
Professor, Graduate School of Medicine, Chiba University
1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, JAPAN
Telephone:+81-43-226-2185, Fax:+81-43-227-1498

[About Program]
Life Innovation Group
Department of Innovation Research
Japan Science and Technology Agency
Takahumi Kawaguchi


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/