The previous studies have demonstrated that senescence of adipose tissue causes insulin resistance by inducing adipose inflammation; however, the underlying mechanism is largely unknown. In the present study Minamino and colleagues have identified semaphorin3E as a key molecule that mediates senescence-induced adipose tissue inflammation. The results indicate that inhibition of semaphorin3E will be a potential therapeutic target for improvement of glucose metabolism in patients with dietary obesity.
Researcher Information
JST PRESTO
Research Area : " Elucidation and control of the mechanisms underlying chronic inflammation"
Research Theme : " Molecular analyses of the mechanisms of age-associated chronic inflammation by using long-lived or aging mouse models"
Journal Information
Author: Ippei Shimizu, Yohko Yoshida, Junji Moriya, Aika Nojima, Akiyoshi Uemura, Yoshio Kobayashi, Tohru Minamino
Title: “Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity”
Cell Metabolism, Published online October 01, 2013
doi: 10.1016/j.cmet.2013.09.001
Contact
[About Research]
Tohru Minamino M.D., Ph.D.
Professor and Chairman, Department of Cardiovascular Biology and Medicine,
Niigata University Graduate School of Medical and Dental Sciences
E-mail: 
[About Program]
Koji Matsuo, Takafumi Kawaguchi
Life Science Group, Department of Innovation Research, JST
E-mail: 