The previous studies have demonstrated that senescence of adipose tissue causes insulin resistance by inducing adipose inflammation; however, the underlying mechanism is largely unknown. In the present study Minamino and colleagues have identified semaphorin3E as a key molecule that mediates senescence-induced adipose tissue inflammation. The results indicate that inhibition of semaphorin3E will be a potential therapeutic target for improvement of glucose metabolism in patients with dietary obesity.
Research Area : " Elucidation and control of the mechanisms underlying chronic inflammation"
Research Theme : " Molecular analyses of the mechanisms of age-associated chronic inflammation by using long-lived or aging mouse models"
Author: Ippei Shimizu, Yohko Yoshida, Junji Moriya, Aika Nojima, Akiyoshi Uemura, Yoshio Kobayashi, Tohru Minamino
Title: “Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity”
Cell Metabolism, Published online October 01, 2013
Tohru Minamino M.D., Ph.D.
Professor and Chairman, Department of Cardiovascular Biology and Medicine,
Niigata University Graduate School of Medical and Dental Sciences
Koji Matsuo, Takafumi Kawaguchi
Life Science Group, Department of Innovation Research, JST