Regenerative medicine is demanded to treat heart disease. We found that a combination of the five cardiac-specific factors can directly reprogram human fibroblasts into cardiomyocyte-like cells. The cells beat synchronously in coculture with other cardiomyocytes, suggesting this new technology may facilitate future applications in regenerative medicine.
JST CREST Research Area "Fundamental technologies for medicine concerning the generation and regulation of induced pluripotent stem (iPS) cells", Research Theme: "Direct reprogramming of fibroblasts into cardiomyocytes by defined factors and its application to potential regenerative therapies"
Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Kaneda R, Suzuki T, Kamiya K, Tohyama S, Yuasa S, Kokaji K, Aeba R, Yozu R, Yamagishi H, Kitamura T, Fukuda K, and Ieda M. "Induction of Human Cardiomyocyte-like Cells from Fibroblasts by Defined Factors." Proc. Natl. Acad. Sci. U.S.A., 2013
Masaki Ieda MD.,
Project Assistant Professor, Keio University
Life Innovation Group
Department of Innovation Research
Japan Science and Technology Agency