Inductive stuffs which can induce limb regeneration responses have been sought for a long time. We found such stuffs in axolotl. Gdf5, Fgf2, and Fgf8 application into wounded axolotl skin resulted in a limb. Thus, these three proteins can be used as a regenerative medicine for urodele amphibians. This finding can be expected to make a new approach for limb regeneration in higher vertebrates.
JST PRESTO Research Area “Understanding Life by iPS Cells Technology”
Research Theme “Stepwise regulation of the cellular dedifferentiation”
Aki Makanae, Ayako Hirata, Yasuko Honjo, KazumasaMitogawa and Akira Satoh
“Nerve independent limb induction in axolotls”
Published online in “Developmental Biology”
Akira SATOH, Ph.D.
Associate Professor, Okayama University, R.C.I.S.
Takafumi Kawaguchi, Fumiharu Kimura,
Life Science Group, Department of Innovation Research
Japan Science and Technology Agency (JST)