A new heterogeneous catalyst confined in entangled carbon nanotube network outperformed the conventional catalyst in anti-selective catalytic asymmetric nitroaldol reaction. The catalyst can be repetitively used by facile filtration and the utility of the present catalysis showcased by the enantioselective synthesis of anacetrapib, a drug candidate for anti-hypercholesterolemia.
JST ACT-C (Advanced Catalytic Transformation Program for Carbon Utilization),
Research Area “Creation of Advanced Catalytic Transformation for the Sustainable Manufacturing at Low Energy, Low Environmental Load”,
Research Theme: “Development of Advanced Practical Cooperative Asymmetric Catalysts and Their Application to Streamlining Enantioselective Synthesis of Therapeutics”
Takanori Ogawa, Naoya Kumagai and Masakatsu Shibasaki. “Self-Assembling Nd/Na Heterobimetallic Catalyst Confined in Carbon Nanotube Network.” Angewandte Chemie, International Edition 2013
Link to the article: http://dx.doi.org/10.1002/anie.201302236
Masakatsu Shibasaki Ph.D.
Director, Institute of Microbial Chemistry
Department of Research Project
Japan Science and Technology Agency (JST)