In vivo electrochemical detection of the reduced form of glutathione (GSH) using boron doped diamond (BDD) microelectrode for potential application in the assessment of cancerous tumors is presented. In vivo GSH detection measurements have been performed in human cancer cells inoculated in immunodeficient mice. These measurements have shown that the difference of GSH level between cancerous and normal tissues can be detected. By using BDD microelectrode, it is possible to assess in vivo the decrease in GSH concentration in the tumor after a specific treatment.
JST CREST Research Area “Creation of Innovative Functions of Intelligent Materials on the Basis of Element Strategy”, Research Theme: “Development of Innovative Technologies Using Diamond Electrodes for Improving Environment”
Published in “Scientific Reportsy”, scientific online journal of Nature Publishing Group
Stéphane Fierro, Momoko Yoshikawa, Osamu Nagano, Kenji Yoshimi, Hideyuki Saya and Yasuaki Einaga “In vivo assessment of cancerous tumors using boron doped diamond microelectrode” Scientific Reports, 2, 901, 2012
Yasuaki EINAGA, Ph.D.
Professor, Department of Chemistry, Keio University
Green Innovation Group, Department of Innovation Research, Japan Science and Technology Agency,