Extracellular ATP induced activation of P2X7 receptor-expressing intestinal mast cells and caused the pathogenesis of inflammatory bowel disease. These findings strongly suggest that P2X7 receptor-dependent intestinal mast cell activation could be a novel target for the treatment of intestinal inflammation.
JST CREST Research Area "The Creation of Basic Medical Technologies to Clarify and Control the Mechanisms Underlying Chronic Inflammation",
Research Theme: "Understanding of chronic inflammation for the development of new therapeutic strategies for intestinal inflammatory diseases"
Published in the scientific journal "Nature Communications"
Yosuke Kurashima, Takeaki Amiya, Tomonori Nochi, Kumiko Fujisawa, Takeshi Haraguchi, Hideo Iba, Hiroko Tsutsui, Shintaro Sato, Sachiko Nakajima, Hideki Iijima, Masato Kubo, Jun Kunisawa, and Hiroshi Kiyono
"Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors"
Nature Communications, 3: 1034 (2012)
Link to the article: http://www.nature.com/ncomms/journal/v3/n9/abs/ncomms2023.html
About Research :
Hiroshi Kiyono, DDS, Ph.D.
Professor, The Institute of Medical Science, The University of Tokyo
About Program :
Life Innovation Group, Department of Innovation Research,
Japan Science and Technology Agency