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JST Press Release

Sep. 5, 2012

Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

A novel mechanism in the activation of immune cells during inflammatory bowel disease

Extracellular ATP induced activation of P2X7 receptor-expressing intestinal mast cells and caused the pathogenesis of inflammatory bowel disease. These findings strongly suggest that P2X7 receptor-dependent intestinal mast cell activation could be a novel target for the treatment of intestinal inflammation.

Research Information

JST CREST Research Area "The Creation of Basic Medical Technologies to Clarify and Control the Mechanisms Underlying Chronic Inflammation",
Research Theme: "Understanding of chronic inflammation for the development of new therapeutic strategies for intestinal inflammatory diseases"

Journal Information

Published in the scientific journal "Nature Communications"
Yosuke Kurashima, Takeaki Amiya, Tomonori Nochi, Kumiko Fujisawa, Takeshi Haraguchi, Hideo Iba, Hiroko Tsutsui, Shintaro Sato, Sachiko Nakajima, Hideki Iijima, Masato Kubo, Jun Kunisawa, and Hiroshi Kiyono
"Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors"
Nature Communications, 3: 1034 (2012)
doi: 10.1038/ncomms2023


About Research :

Hiroshi Kiyono, DDS, Ph.D.
Professor, The Institute of Medical Science, The University of Tokyo

About Program :

Tetsuya Ishii,
Life Innovation Group, Department of Innovation Research,
Japan Science and Technology Agency


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/