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JST Press Release

Aug. 31, 2012

Japan Science and Technology Agency (JST)
5-3, Yonbancho, Chiyoda-ku, Tokyo 102-8666

Millionfold improvement of the detection limit of biomarkers for diseases and infections

Single-molecule digital ELISA (Enzyme-Linked Immunosorbent Assay) has realized millionfold improvement of the detection limit of a biomarker for prostate cancer. In the near future, this method will lead to a highly-sensitive portable device for the earliest diagnosis of many diseases and infections.

Research Information

JST CREST Research Area "Creation of Nanosystems with Novel Functions through Process Integration", Research Theme : "Digital counting systems for biological assay"

Journal Information

Published in "Lab on a chip", scientific journal of Royal Society of Chemistry
Soo Hyeon Kim, Shino Iwai, Suguru Araki, Shouichi Sakakihara, Ryota Iino and Hiroyuki Noji. "
Large-scale femtoliter droplet array for digital counting of single biomolecules"
Lab on a chip, 2012
doi: 10.1039/C2LC40632B


About Research :

Ryota IINO Ph.D.
Lecturer, Department of Applied Chemistry, School of Engineering, The University of Tokyo

About Program :

Masashi Furukawa,
Green Innovation Group, Department of Innovation Research,
Japan Science and Technology Agency,


JST, an integrated organization of science and technology in Japan, establishes an infrastructure for the entire process from the creation of knowledge to the return to the society. For more information, visit http://www.jst.go.jp/EN/