Project

Completed Research

Selected in Fiscal 2002

Steroid receptors as regulatory factors for gene expression
[ Research representative : Shigeaki Kato ]
Research representative
Shigeaki Kato (Professor, Institute of Molecular and Cellular Biosciences, The University of Tokyo)
Source program
Former CREST, "Genetic Programming"
Overview
In his previous studies, the researcher investigated the transcriptional regulations by nuclear steroid receptors, and successfully led to identify co-regulators for nuclear receptors and characterize their physiological significance in intact animals.
This research will focus on "biochemical identification of novel nuclear factors and their complexes that co-regulate the transactivation function of nuclear receptors" and "evaluating the tissue- and stage- specific function of nuclear receptors and their coregulators," in an attempt to elucidate the molecular mechanism of gene expressions by nuclear steroid receptors.
Regeneration of hippocampal neurons following delayed neuronal death
[ Research representative : Takaaki Kirino ]
Research representative
Takaaki Kirino (Professor, Graduate School of Medicine, The University of Tokyo)
Source program
CREST, "Protecting the Brain"
Overview
In the previous studies, the researcher confirmed that the neuronal stem cells in the hippocampal CA1 region can regenerate and restore the structure and function of the neuronal circuitry.
This research is intended to clarify the optimal conditions to induce regeneration and functional recovery in the hippocampus.
Elucidation of language acquisition devices based on the brain functions of language
[ Research representative : Kuniyoshi Sakai ]
Research representative
Kuniyoshi Sakai (Associate Professor, Graduate School of Arts and Sciences, The University of Tokyo)
Source program
Former CREST, "Creating the Brain"
Overview
In his previous studies, the researcher identified the brain region of language ability concerning grammatical processing, established a language analysis paradigm, and developed natural language processing modeled on the brain, among other results.
This research will conduct brain functional imaging of language, clarify the functional localization and functional differentiation of language acquisition devices, and attempt to elucidate the calculation principles of universal grammar in the brain.
Developing a drug which targets cell death signal transmission molecules
[ Research representative : Yoshihide Tsujimoto ]
Research representative
Yoshihide Tsujimoto (Professor, Graduate School of Medicine, Osaka University)
Source program
CREST, "Protecting the Brain"
Overview
In his previous studies, the researcher showed that the mitochondrial membrane channel could be a target molecule for curing diseases resulting from the collapse of cell death control, and simultaneously presented a candidate drug.
This research will further systematically analyze the molecular mechanism of cell death, in an attempt to discover new target molecules for a cure of diseases as well as to analyze the effectiveness of drug candidates, among other tasks.
Total synthesis of ciguatoxins-preparation of antibodies, prevention of seafood poisoning, and development of neuroscience
[ Research representative : Masahiro Hirama ]
Research representative
Masahiro Hirama (Professor, Graduate School of Science, Tohoku University)
Source program
CREST, "Single Molecule and Atom Level Reactions"
Overview
In his previous studies, the researcher succeeded in the total synthesis of CTX3C, an important congener of ciguatoxins, that cause ciguatera seafood poisoning particularly in tropical and subtropical regions.
In this research the researcher intends to synthesize more important congeners of ciguatoxins, and to elucidate the interaction between ciguatoxins and sodium channel, and furthermore to prevent ciguatera seafood poisoning by preparing anti-ciguatoxin antibodies and their application to the highly sensitive immunoassay system.
Developing transportable superconducting millimeter wave atmospheric molecule meters
[ Research representative : Yasuo Fukui ]
Research representative
Yasuo Fukui (Professor, Graduate School of Science, Nagoya University)
Source program
CREST, "Mechanism of Global Change"
Overview
In his previous studies, the researcher developed a high-sensitivity, atmospheric, millimeter-wave molecular spectral observation device equipped with a superconducting receiver. This equipment made it possible for the first time ever to observe the distributions of different kinds of molecules that destroy the ozone layer by time and altitude in the mid-latitude zones of the Southern Hemisphere.
This research will continue these observations, measure and analyze the changes with time and other phenomena in detail, reduce the size of the system and cut its power consumption, and form a network of observation sites.
Global Biomass Estimation Practical Use Project
[ Research representative : Yoshiaki Honda ]
Research representative
Yoshiaki Honda (Associate Professor, Center for Environmental Remote Sensing, Chiba University)
Source program
CREST, "Mechanism of Global Change"
Overview
In his previous studies, the researcher succeeded in developing a method of accurately monitoring biomass in herbaceous vegetation based on satellite data.
This method of multi-angular observation from a satellite will be used to develop a method of estimating biomass with plant height information in order to more accurately monitor biomass in forest vegetation including trees. This will make it possible to monitor how mankind has been using vegetation biomass resources for the past twenty years.
Sustainable hibitat system that maximizes throughput
[ Research representative : Yasunori Matsufuji ]
Research representative
Yasunori Matsufuji (Professor, Graduate School of Human-Environmental Studies, Kyushu University)
Source program
Former CREST, "Social Systems for Better Environment Performance"
Overview
In his previous studies, the researcher demonstrated that bricks made of industrial waste or similar waste material can be used to produce recyclable housing easy on its occupants and the environment.
This research is intended to confirm the commercializability of these bricks and increase the degree of completing such housing based on this material.
Formation of neuronal connections and neuronal migration in the brain
[ Research representative : Fujio Murakami ]
Research representative
Fujio Murakami (Dean, Professor, Graduate School of Frontier Biosciences, Osaka University)
Source program
CREST, "Understanding the Brain (Mechanisms of Brain)"
Overview
In his previous studies, the researcher successfully visualized the migratory behaviror of neurons which is essential for the formation of correct neuronal circuits.
This research will clarify the relation between the mechanism of neuronal circuit formation and that of neuronal migration in an attempt to obtain an integrated understanding of both phenomena.
Developing applications for self-structuring and organization-creating supercooled metals
[ Research representative : Akihisa Inoue ]
Research representative
Akihisa Inoue (Director and Professor, Institute for Materials Research, Tohoku University)
Source program
Former ERATO, "INOUE Superliquid Glass Project"
Overview
In his previous studies, the researcher conducted comprehensive studies on metallic supercooled liquids, which revealed some knowledge about the stabilization conditions of metallic supercooled liquids, along with their processability, phase change and other control factors.
This research will be based on those past findings to explore the applicability of metallic supercooled liquids as materials for permanent magnets, optical discs and mild–magnetism, large-width plates.
Manybody quantum correlation of the electron system and its optical control functions
[ Research representative : Makoto Kuwata-Gonokami ]
Research representative
Makoto Kuwata-Gonokami (Professor, Graduate School of Engineering, The University of Tokyo)
Source program
Former ERATO, "GONOKAMI Cooperative Excitation Project"
Overview
In his previous studies, the researcher attempted to produce collective quantum effects in wide-ranging substances by precisely controlling laser beams in that process, and thus obtained knowledge of the manybody correlation effects on the nonlinear optical response of semiconductors.
This research will further promote this study on physical phenomena that can be the bases for various applications such as optical switches, optical signal buffers and other devices.
Specific adsorption Phenomenan on Carbon nanotubes -Application of Cabon nanotubes to hydrogen strage and Bio technology-
[ Research representative : Sumio Iijima ]
Research representative
Sumio Iijima (Professor, Faculty of Science and Technology, Meijo University)
Source program
Former ICORP, "Nanotubulites Project"
Overview
In his previous studies, the researcher elucidated the growth mechanism, manufacturing method, structure, nature of carbon nanotubes and similar substances, and during that process clarified that these substances are applicable to electronic devices, fuel cells, catalysts, storage of particular molecules and other uses.
This research have considered, among these characteristics, the adsorption phenomena of particular kinds of molecules is interesting in an attempt to increase the amount of adsorption and extend these phenomena to biotechnology.
Functional analysis and chloroplastic motion of photoreceptor phototropin 2
[ Research representative : Takatoshi Kagawa ]
Research representative
Takatoshi Kagawa (Associate Professor, Institute of Applied Biochemistry, University of Tsukuba)
Source program
Former PRESTO, "Unit Process and Combined Circuit"
Overview
In our previous studies, it has been found by genetic analysis of Arabidopsis thaliana that phototropin 1 and 2 regulate chloroplast accumulation and avoidance movement.
In this studies, in order to reveal functional domains of phototropin 2, we analysis the domains for chloroplast relocation movement, phototropism and stomatal opening using transgenic plants introduced modified phototropin 2 genes.
Ultrafast photoelectron imaging of solution chemistry
[ Research representative : Toshinori Suzuki ]
Research representative
Toshinori Suzuki (Chief Scientist, Chemical Dynamics Laboratory, Discovery Research Institute, RIKEN)
Source program
Former PRESTO, "Structure and Transformation"
Overview
In his previous studies, the researcher developed a method of femtosecond time-resolved photoelectron imaging method.
In this research, we employ this method, developped for observing gas-phase reactions, to observe ultrafast electronic dynamics in solution and establish it as a new tool to study solution chemistry.
Functional imaging in developmental brain science
[ Research representative : Gentaro Taga ]
Research representative
Gentaro Taga (Professor, Graduate School of Education, The University of Tokyo)
Source program
Former PRESTO, "Information and Human Activity"
Overview
In his previous studies, the researcher succeeded in imaging the visual cortex of two-month-old infants watching an object in a natural state for the first time ever.
This research will promote studies based on optical topography in an attempt to elucidate the mechanism of differentiating and integrating brain functions in the developmental process.
Steric control of newly developed practical hydrolytic reactions with high concentrations
[ Research representative : Makoto Tokunaga ]
Research representative
Makoto Tokunaga (Associate Professor, Catalysis Research Center, Hokkaido University)
Source program
Former PRESTO, "Form and Function"
Overview
In his previous studies, the researcher found a new catalyst that can hydrolyze esters and ethers under high concentration conditions.
This research will further improve this new catalyst, thereby developing novel catalysts that can control stereochemistry in hydrolysis reactions to achieve their industrial application.
Equation division and reduction division: Comprehensive elucidation of the distribution mechanism for chromosomes
[ Research representative : Yoshinori Watanabe ]
Research representative
Yoshinori Watanabe (Associate Professor, Graduate School of Science, The University of Tokyo)
Source program
Former PRESTO, "Unit Process and Combined Circuit"
Overview
In his previous studies, the researcher clarified that chromosome-adhesion factors Rad21 and Rec8 play central roles in determining the chromosome distribution patterns of somatic cell division and meiotic division (equation and reduction division).
This research will search for centromere-constituent factors that work cooperatively with cohesins and related control factors by using a molecular genetic method and promoting related analysis, in an attempt to obtain an integrated understanding of the chromosome distribution mechanism of somatic cell division and meiotic division that are common to eukaryotes in general.
(Note) The titles, organizations, and overviews described above are as of the time when the projects started.

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