Creation of Innovative Technology for Medical Applications Based on the Global Analyses and Regulation of Disease-Related Metabolites

Strategic Objects

Creation of core technologies for early-stage drug discovery through the investigation of disease-specific profiles of biomolecules

Research Supervisor


Yoshiya Oda(President, Biomarkers and Personalized Medicine Core Function Unit, Eisai Product Creation Systems)

Outline

The aim of this Research Area is to create breakthrough technology platforms based on biomolecular dynamics analysis, the outcomes of which will contribute to medical applications such as drug discovery, disease diagnosis, and prevention. The technology platforms should increase the capacity of current systems to find, identify, and quantify disease-related metabolites and their associated factors as potential target molecules for medical applications.

In particular, this Research Area will focus on the development of ultrasensitive detection methods to discover novel disease-associated factors, accurate identification and quantification of newly detected factors, drastically higher throughput analysis, multiplex analysis, and related information technologies. Simultaneously, efforts will be made to establish and advance a series of technology for target analysis based on the repositioning of known physiologically active compounds to understand target metabolites, proteins, and metabolic pathways, as well as for elucidating the mode-of-action of potent compounds where the molecular mechanisms are still unknown. By diversifying current technological approaches, these challenges promise to contribute a proof of concept of human disease control by taking full advantage of the information obtained about core biomolecules as potential targets for medical applications.

This Research Area encourages interdisciplinary approaches ranging from nanotechnology, synthetic chemistry, engineering, and other related fields, to the life sciences, expecting them to culminate in seminal, often transformative research that leads to innovation. Moreover, research management will cooperate closely with the corresponding Core Research for Evolutionary Science and Technology (CREST) Research Area (operations will be transferred to A-MED in April 2015) to facilitate close-knit collaboration. Thus, individual PRESTO researchers should take responsibility for their own projects and for the team, as members of the virtual-network-type institute, to ensure that mutual benefits are accrued by the two Research Areas.

Year Started : 2013

Asuka Inoue

Research Associate, Tohoku University

Screening and identification of G protein-coupled receptors (GPCRs) that respond to disease-related metabolites.

Toru Komatsu

Assistant Professor, The University of Tokyo

Discovery of Novel Biomarker and Drug Target Proteins by Visualizing Dynamic Protein Functions.

Akira Shigenaga

Assistant Professor, The University of Tokushima

Development of innovative tools for identification and functional analysis of target proteins with which biologically active compounds interact.

Takahiro Shibata

Assistant Professor, Nagoya University

Establishment of analytical method of protein adductome.

Yuki Sugiura

Lecturer, School of Medicine, Keio University

Understanding the basic principles of disease progression by novel molecular imaging technique of metabolic fluxes in vivo.

Motohiro Nishida

Professor, National Institutes of Natural Sciences

Establishment of the molecular basis underling regulation of redox homeostasis based on sulfur circulation and metabolism.

Kenichi Yamada

Associate Professor, Kyushu University

Development of fluorescent and mass spectrometry multi-probe for lipid derived radicals and application to animal disease models.

Year Started : 2015

Establishment of Metabolite-based Ubiquitin Ligase Control Engineering

Research Director:
Takumi Ito(Assistant Professor, Department of Nanoparticle Translational Research, Tokyo Medical University)

Functional RNA modomics for understading neurological diseases

Research Director:
Fan-Yan Wei(Assistant Professor, Faculty of Life Sciences, Kumamoto University)

Development of a novel method for prevention, diagnosis, and treatment of seasonal and pandemic influenza based on exosome RNA analysis

Research Director:
Hiroyuki Oshiumi(Professor, Faculty of Life Sciences, Kumamoto University)

High-throughput Functional Genomics Screenings to Discover Novel Anti-Cancer Metabolomics Targets by Combining Human shRNA and Microbial cDNA Libraries.

Research Director:
Hiroto Katoh(Assistant Professor, Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University)

Development of the New Analytical Methods for the Binding Modes of Target Proteins Using LA-LDI MS

Research Director:
Masaki Kita(Associate Professor, Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba)

Examination of synaptic stress response for the drug discovery of neuropsychiatric disorders.

Research Director:
Akiko Hayashi-Takagi(Associate Professor, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo)

Development of fundamental technology for preventive and therapeutic medicine through intestinal metabolites-targeted approach

Research Director:
Shinji Fukuda(Project Associate Professor, Graduate School of Media and Governance, Keio University)

Development of trans-omic analysis for rational design of multicomponent therapeutics and control of multifactorial metabolic diseases

Research Director:
Katsuyuki Yugi(Research Associate, Graduate School of Science, Department of Biolotical Sciences, The University of Tokyo)

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