[Takuma Kasai] Advanced NMR analysis with information-encoded samples, integrated measurements, and tensor decomposition

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Takuma Kasai

Takuma Kasai

Quantitative Biology Center, RIKEN
Research Scientist

Outline

Nuclear magnetic resonance (NMR) is a powerful method to investigate structures and dynamics of proteins at atomic resolution. However, the application of NMR for large proteins or proteins in living cells is limited due to enhanced relaxation and signal overlap. To overcome these difficulties, I integrate several new approaches: elaborated isotope labeling scheme to encode information for assignments, combined NMR measurements for simultaneous assignments and analyses, tensor decomposition for signal separation. This strategy will help application of NMR for various proteins in challenging situations.

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