[Takeshi Maruyama] Opt-CRISPRed mouse system for understanding the behavior of transformed cells

Research Director

Takeshi Maruyama

Takeshi Maruyama

Institute for Genetic Medicine, Hokkaido University
Assistant Professor

Outline

Transformed cells are extruded from an epithelial monolayer in a short time in vitro and ex vivo. To observe the short-time behavior predictable in vivo, accurate biotechniques are required, which allow the spatiotemporal induction of oncogenic mutagenesis onto the epithelium tissue in a given organ. In this regard, we shall create Precision Opt-CRISPRed mouse system, and induce the transformed cells in vivo using implantable LED nanodevices. The optical mouse model and elucidation of the extrusion mechanisms would lead to the development of novel therapies for cancer prevention.

Quick Access

Quick Access

 News

arrow On-going

arrow Completed

Program

  • CREST
  • PRESTO
  • ACT-I
  • ERATO
  • ACT-C
  • ACCEL
  • ALCA
  • RISTEX
Finish programs
  • Pamphlet
  • ProjectDB
  • GlobalActivity
  • Diversity-EN
  • OS_Policy-EN
  • Question-E