[Kazuo Takayama] Development of a technology for light-inducible genome editing and gene expression modification in target organ

Research Director

Kazuo Takayama

Kazuo Takayama

Graduate School of Pharmaceutical Sciences, Osaka University
Specially Appointed Assistant Professor

Outline

In this project, we will develop a photoactivatable CRISPR/Cas9 system for genome editing and gene expression modification. To apply this system to in vivo experiments, we are going to use adenovirus vector-mediated gene transfer technology. This adenovirus vector-mediated optogenetically-modified CRISPR/Cas9 system will enable to perform light-inducible genome editing and gene expression modification with high spatial-temporal resolution in various organs or species. By developing this system, we believe that novel life science research and treatment of disease can be performed.

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