[Noriaki Ohkawa] Creation of new methods for manipulation of memory by extraction of characteristic patterns of engram

Research Director

Noriaki Ohkawa

Noriaki Ohkawa

Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
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Outline

Memory is encoded in a specific neuronal ensemble that is activated during a corresponding learning event. The ensemble is called an “engram”. In this project, I will propose to extract especial activity patterns from engram cells by visualization of activity of engram and non-engram cells in pre-, post-, and learning periods. Moreover, I will apply the information of extracted activity pattern of engram to optogenetic manipulation of engram cells, and then I will check qualitative changing of corresponding memory. These trials will open out possibilities to create new methods for manipulation of memory.

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