[Masahito Hosokawa] Massively parallel single-cell genomics for elucidation of intra-tissue genetic heterogeneity

Research Director

Masahito Hosokawa

Masahito Hosokawa

Japan Science and Technology Agency
PRESTO Researcher

Outline

This study aims to develop droplet-based microfluidics for massively parallel single-cell genomics, to elucidate intra-tissue genetic heterogeneity at the single-cell resolution. Most tumors display extensive intra-tumor heterogeneity, with various subpopulations of cells contains different mutations. For understanding these intra-tissue heterogeneities, ideal single-cell genomics methods should analyze tens of thousands of single cells in an efficient manner. In this study, I will develop droplet-based microfluidic techniques to produce the compartmentalized reaction environments for single-cell sequencing.

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