[Nozomu Yachie] DNA Barclock Technology to track cellular lineages at the single cell resolution

Presto Researcher

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Nozomu Yachie

Research Center for Advanced Science and Technology, The University of Tokyo
Associate Professor

Outline

Despite the importance of tracking spatiotemporal dynamics of cellular developments at the single cell resolution, no such a technology has been developed. This project aims to develop DNA Barclock, a genetic circuit which accumulate DNA mutations on a short synthetic DNA sequence along with cell divisions, to track cellular lineages by highly-parallel short-read sequencing and computational lineage tree reconstruction.

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