[Akiko Hayashi-Takagi] Examination of synaptic stress response for the drug discovery of neuropsychiatric disorders.

PRESTO Researcher

Akiko Hayashi-Takagi

Akiko Hayashi-Takagi

Institute for Molecular and Cellular Regulation, Gunma University
Professor

Outline

The deterioration of the synapses has attracted attention as the pathophysiology of neuropsychiatric disorders, and synaptic responses against the stress, such as oxidative, endoplasmic reticulum, and carbonyl stress, is now being considered as a possible causal signaling in these diseases. Thus, I will develop the high throughput in vitro screening system as well as in vivo brain imaging of disease model so that quantitative measurement of the synaptic deterioration and stress-related metabolites will be performed. Together with behavioral assessment, I aim to identify a novel therapeutic target for neuropsychiatric disorders.

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