1. Y. Yamaguchi, N. Inukai, T. Narita, T. Wada and H. Handa Evidence that NELF represses transcription elongation through binding to a DSIF/RNA polymerase II complex and RNA Molecular and Cellular Biology Vol. 22 (9): 2918-2927 (2002) 2. K. Nakada, T. Ono and J. Hayashi A novel defense system of mitochondria in mice and human subjects for preventing expression of mitochondrial dysfunction by pathogenic mutant mtDNAs Mitochondrion Vol. 2: 59-70 (2002) 3. T. Shonai, M. Adachi, K. Sakata, M. Takekawa, T. Endo, K. Imai and M. Hareyama MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells Cell Death and Differentiation Vol. 9: 963-971 (2002) 4. N. Takahashi, T. Kawada, T. Yamamoto, T. Gotoh, A. Taimatsu, N. Aoki, H. Kawasaki, K. Taira, K. Yokoyama, Y. Kamei and T. Fushiki Overexpression and ribozyme-mediated targeting of transcriptional coactivators, CREB binding protein(CBP) and p300, revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator- activated receptor-gamma(PPAR-gamma) Journal of Biological Chemistry Vol. 277: 16906-16912 (2002) 5. C. Krawczyk, A. Olivera-dos-Santos, T. Sasaki, E. Griffiths, P. Ohashi, S. Snapper, F. Alt and J. Penninger Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells Immunity Vol.16: 331-343 (2002) 6. T. Sasaki, A. Suzuki, J. Sasaki and J. Penninger Phosphoinositide 3-kinases in immunity: Lessons from knockout mice Journal of Biochemistry Vol. 131: 495-501 (2002) 7. T. Muratani, T. Minami, U. Enomoto, M. Sakai, E. Okuda-Ashitaka, K. Kiyokane, H. Mori and S. Ito Characterization of Nociceptin/Orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2-methylquinolin-6-yl 9-2-(4-ethylphenoxymethyl) benzamide monohydrochloride. J. Pharmacol. Exper. Ther. Vol. 303: 424-430 (2002) 8. S. Ikeda, H. Miyazaki, T. Nakatani, Y. Kai, Y. Kamei, S. Miura, N. Tsuboyama-Kasaoka and O. Ezaki Up-regulation of SREBＰ-1c and lipogenic gene in skeletal muscles after exercise training Biochemical and Biophysical Research Communications Vol. 296: 395-400 (2002) 9. K. Inoue, H. Osaka, Virginia C. Thurston, Joe T. R. Clarke, A. Yoneyama, Lisa Rosenbarker, Thomas D. Bird, M. E. Hodes, Lisa G. Shaffer and James R. Lupkin Genomic rearrangements Resulting in PLP1 Deletion Occur by Nonhomologous end joining and Cause Different Dysmyelinating Phenotypes in Males and Females Am. J. Hum. Genet. Vol. 71 (4): 838-853 (2002) 10. M. Yamazaki, H. Miyazaki, H. Watanabe, T. Sasaki, T. Maehama, M. Frohman and Y. Kanaho Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling Journal of Biological Chemistry Vol. 277: 17226-17230 (2002) 11. N. Ito, T. Yokomizo, T. Sasaki, H. Kurosu, J. Penninger, Y. Kanaho, T. Katada, K. Hanaoka and T. Shimizu Requirement of phosphatidylinositol 3-kinase-activation and Ca influx for leukotriene B4-induced enzyme release Journal of Biological Chemistry Vol. 277: 44898-44904 (2002) 12. M. Crackower, G. Oudit, I. Kozieradzki1, R. Sarao, T. Sasaki, E. Hirsch, A. Suzuki, T. Shioi, J. Sasaki, R. Sah, H. Cheng, V. Rybin, G. Lembo, L. Fratta, A. Oliveira-dos-Santos, J. Benovic, R. Kahn1, S. Izumo, S. Steinberg, M. Wymann, P. Backx, and J. Penninger Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathway Cell Vol. 110: 737-749 (2002) 13. K. Nakamura, K. Tanoue, T. Satoh, M. Takekawa, M. Watanabe, H. Shima and K. Kikuchi A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurred substitution that affects substrate specificity. J. Biochem. Vol.132: 463-470 (2002) 14. T. Abe, T. Suzuki, S. Ito, M. Unno, T. Onogawa and T. Tokui The human hepatocyte-specific organic anion transporter encoded by the SLC21A8 gene Gastroenterology Vol. 122: 1545-1546 (2002) 15. Y. Kamei, J. Mizukami, S. Miura, M. Suzuki, N. Takahashi, T. Kawada, T. Taniguchi and O. Ezaki A forkhead transcription factor FKHR up-regulates lipoprotein lipase expression in skeletal muscle FEBS Letters Vol. 536: 232−236(2003) 16. M. Takekawa, K. Tatebayashi, F. Itoh, M. Adachi, K. Imai and H. Saito Smad-dependent GADD45β expression mediates delayed activation of p38 MAP kinase by TGF-β The EMBO Journal Vol. 21: 6473-6482(2002) 17. S. Mitsuhashi, H. Shima, N. Tamura, N. Matsuura, M. Takekawa, T. Urano, M. Ubukata and K. Kikuchi Usage of tautomycetin, a novel inhibitor of protein phosphatase 1(PP1) reveals that PP1 is a positive regulator of Raf-1 in COS-7 cells. Journal of Biological Chemistry Vol. 278: 82-88(2003) 18. 佐々木雄彦 心臓におけるPI3Kアイソザイム特異的な機能 実験医学 Vol. 20: 18 (2002) 19. T. Mabuchi, S. Matsumura, E. Okuda-Ashitaka, T. Kitano, H. Kojima, T. Nagano, T. Minami and S. Ito Attenuation of neuropathic pain by nociceptin/orphanin FQ antagonist is mediated by inhibition of nitric oxide production Eur. J. Neurosci. Vol. 17: 1384-1392(2003) 20. S. Sakon, X. Xue, M. Takekawa, T. Okazaki, Y. Kojima, J-H. Pia, T. Sasazuki, H. Yagita, K. Okumura, T. Doi and H. Nakano NK-kappa B inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death The EMBO Journal Vol. 22: 3898-3909(2003) 21. K. Tatebayashi, M. Takekawa and H. Saito A docking site that determining specificity of Pbs2 MAPKK to Ssk2/Ssk22 MAPKKKs in yeast HOG pathway The EMBO Journal Vol. 22: 3624-3634(2003) 22. 吉田秀郎、松居利江、細川暢子、Randal J. Kaufman、永田和宏、森和俊 A Time-dependent phase shift in the mammalian unfolded protein response Developmental Cell Vol. 4: 265-271 (2003) 23. T. Narita, Y. Yamaguchi, K. Yano, S. Sugimoto, S. Chanarat, T. Wada, D. Kim, J. Hasegawa, M. Omori, N. Inukai, M. Endoh, T. Yamada and H. Handa Human transcription elongation factor NELF: Identification of novel subunits and reconstitution of the functionally active complex Molecular and Cellular Biology Vol. 23 : 1863-1873, 2003. 24. Y. Ohba, K. Kurokawa and M. Matsuda Mechanism of the spatio-temporal regulation of Ras and Rap1 The EMBO Journal Vol. 22(4): 859-869(2003) 25. C. H. Wu, Y. Yamaguchi, L. Benjamin, M. Horvat-Gordon, J. Washinski, E. Enerly, J. Larsson, A. Lambertsson, H. Handa and D. S. Gilmour NELF and DSIF cause promoter proximal pausing on the hsp70 promoter in Drosophila. Genes and Development Vol. 17 (11): 1402-1414(2003) 26. U. Watanabe, T. Shimura, N. Sako, J. Kitagawa, T. Shingai, E. Watanabe, M. Noda and T. Yamamoto A comparison of voluntary salt-intake behavior in Nax-gene deficient and wild-type mice with reference to peripheral taste inputs. Brain Reserch Vol. 967: 247-256(2003) 27. M. Yoshizawa, M. Sone, N. Matsuo, T. Nagase, O. Ohara, Y. Nabeshima and M. Hoshino Dynamic and coordinated expression profile of dbｌ-family guanine nucleotide exchange factors in the developing mouse brain Gene Expression Patterns Vol. 3: 375-381(2003) 28. A. Suzuki, S. Itami, M. Ohishi, K. Hamada, T. Inoue, N. Komazawa, H. Senoo, T. Sasaki, J. Takeda, M. Manabe, T. Mak and T. Nakano Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation Cancer Research Vol. 63: 674-681(2003) 29. J. Irie-Sasaki, T. Sasaki and J. M. Penninger CD45-regulated signaling pathways Current Topics Medical Chemistry Vol. 3: 783-796(2003) 30. M. Nogami, M. Yamazaki, H. Watanabe, Y. Okabayashi, Y. Kido, M. Kasuga, T. Sasaki, T. Maehama and Y. Kanaho Requirement of autophosphorylated tyrosine 992 of EGF receptor and docking protein phospholipase Cγ1 for membrane ruffle formation FEBS Letter Vol. 536: 71-76(2003) 31. H. Kishimoto, K. Nakagawa, T. Watanabe, D. Kitagawa, H. Momose, J. Seo, G. Nishitai, N. Shimizu, S. Ohata, S. Tanemura, S. Asaka, T. Goto, H. Fukushi, H. Yoshida, A. Suzuki, T. Sasaki, T. Wada, J. Penninger, H. Nishina and T. Katada Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. Journal of Biological Chemistry Vol. 278: 16595-16601(2003) 32. A. Suzuki, T. Kaisho, M. Ohishi, M. Tsukio-Yamaguchi, T. Tsubata, PA. Koni, T. Sasaki, TW Mak and T. Nakano Critical roles of Pten in B cell homeostatis and immunoglobulin class switch recombination Journal of Experimental Medicine Vol. 197: 657-667(2003) 33. H. Kishimoto, K. Hamada, M. Saunders, S. Backman, T. Sasaki, T. Nakano, T. Mak and A. Suzuki Physiological functions of Pten in mouse tissues Cell Structure and Function 34. A. Kim, T. Sasaki and M. Chano JNK interacting protein 1 promotes Akt1 activation Journal of Biological Chemistry Vol. 278: 29830-29836, 2003. 35. K. Nishikawa, Hang Li, R. Kawamura, H. Osaka, Yu-Lai Wang, Y. Hara, T. Hirokawa, Y. Manago, T. Amano, M. Noda, S. Aoki and K. Wada Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants Biochemical and Biophysical Research Communications Vol. 304: 176-183(2003) 36. H. Osaka, Y.-L. Wang, K. Tanaka, S. Takizawa, R. Setsuie, Hang Li, Y. Sato, K. Nishikawa, Ying-Jie Sun, M. Sakurai, T. Harada, Y. Hara, I. Kimura, S. Chiba, K. Namikawa, H. Kiyama, M. Noda, S. Aoki and K. Wada Ubiquitin carboxy-terminal hydrolase L1 binds to and satabilizes monoubiquitin in neuron Human Molecular Genetics Vol. 12: 1945-1958(2003) 37. T. Iwawaki, R. Akai, K. Kohno and M. Miura A transgenic mouse model for monitoring endoplasmic reticulum stress Nature Medicine Vol. 10: 98-102(2004) 38. A. Satoh, M.Toyota, F. Itoh, Y. Sasaki, H. Suzuki, K. Ogi, T. Kikuchi, H. Mita, T. Yamashita, T. Kojima, M. Kusano, M. Fujita, M. Hosokawa, T. Endo, T. Tokino and K. Imai Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer Cancer Research Vol. 63: 8606-8613(2003) 39. A. Sakakibara, Y. Ohba, K. Kurokawa., M. Matsuda and S. Hattori Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation Journal of Cell Science Vol. 115(Pt24): 4915-4924(2002) 40. R. E. Itoh, K. Kurokawa, Y. Ohba, H. Yoshizaki, N. Mochizuki, and M. Matsuda Activation of Rac and Cdc42 video-imaged by FRET-based single-molecule probes in the membrane of living cells Molecular and Cellullar Biology Vol. 22(18): 6582-6591(2002) 41. H. Yoshizaki, Y. Ohba, K. Kurokawa, R. E. Itoh, T. Nakamura, N. Mochizuki, K. Nagashima and M. Matsuda Activity of Rho-family GTPases during cell division as cisualized with FRET-based probes Journal of Cell Biology Vol. 162(2): 223-232(2003) 42. S. Giuriato, C. Pesesse, S. Bodin, T. Sasaki, C. Viala, E. Marion, J. Penninger, S. Schurmans, C. Erneux and B. Payrastre SH2 domain containing inositol 5-phosphatase 1 and 2 in blood platelets: interaction and respective role in the control of phosphatidylinositol 3,4,5-trisphosphate level Biochemical Journal Vol. 376: 199-207(2003) 43. G. Oudit, M. Crackower, U. Eriksson, R. Sarao, I. Kozieradzki, T. Sasaki, J. Sasaki, D. Gidrewicz, V. Rybin, T. Wada, S. Steinberg, P. Backx and J. Penninger Phosphoinositide 3-kinaseγ-deficient mice are protected from isoproterenol-induced heart failure Circulation Vol. 108: 2147-2152(2003) 44. M. Woo, R. Hakem, C. Furlonger, A. Hakem, G. Duncan, T. Sasaki, D. Bouchard, L. Lu, G. Wu, C. Paige and T. Mak Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity Nat. Immunol. Vol. 4: 1016-1022(2003) 45. I. Khan, H. Osaka, S. Stanislaus, R.M. Calvo, T. Deerinck, T.L. Yaksh TL and P. Taylor Nicotinic acetylcholine receptor distribution in relation to spinal neurotransmission pathways J. Comp. Neurol. Vol. 467(1): 44-59(2003) 46. T. Harada, C. Harada, Y.L. Wang, H. Osaka, K. Amanai, K. Tanaka, S. Takizawa, R. Setsuie, M. Sakurai, Y. Sato, M. Noda and K. Wada Role of ubiquitin carboxy terminal hydrolase-LS1 in neural cell apoptosis induced by ischemic retinal injury in vivo Am. J. Pathol. Vo. 164(1): 59-64(2004) 47. H. Kusuhara, Z. He, Y. Nagata, Y. Nozaki, T. Ito, H. Masuda, P.J. Meier, T. Abe and Y. Sugiyama Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus Pharm. Res. Vol. 20: 720-727( 2003) 48. T. Suzuki, T. Onogawa, N. Asano, H. Mizutamari, T. Mikkaichi, M. Tanemoto, M. Abe, F. Satoh, M. Unno, K. Nunoki, M. Suzuki, T. Hishinuma, J. Goto, T. Shimosegawa, S. Matsuno, S. Ito and T. Abe Identification and characterization of novel rat and human gonad specific organic anion transporters Mol. Endocrinol. Vol. 17: 1203-1215( 2003) 49. S. Ohtsuki, T. Takizawa, H. Takanaga, N. Terasaki, T. Kitazawa, S. Sasaki, T. Abe, K. Hosoya, and T. Terasaki In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate Mol. Pharmacol. Vol. 63: 532-537(2003) 50. K. Sato, J. Sugawara, T. Sato, H. Mizutamari, T. Suzuki, A. Ito, T. Mikkaichi, T. Onogawa, M. Tanemoto, M. Unno, T. Abe and K. Okamura Expression of organic anion transporting polypeptide E (OATP-E) in human placenta. Placenta Vol. 24: 144-148( 2003) 51. T. Kodawara, S. Masuda, H. Wakasugi, Y. Uwai, T. Futami, H. Saito, T. Abe and K. Inu Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver. Pharmaceutical Res. Vol. 19: 738-43( 2002) 52. Y. Shitara, D. Sugiyama, H. Kusuhara, Y. Kato, T. Abe, P.J. Meier, T. Itoh and Y. Sugiyama Comparative inhibitory effects of different compounds on rat oatp1 (slc21a1)- and oatp2 (Slc21a5)-mediated transport. Pharmaceutical Res. Vol. 19: 147-153 ( 2002) 53. A. Ito, K. Yamaguchi, T. Onogawa, M. Unno, T. Suzuki, T. Nishio, T. Suzuki, H. Sasano, T. Abe, and M. Tamai. Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Invest. Ophthalmol. Vis. Sci. Vol. 43: 858-863( 2002) 54. M. Sasaki, H. Suzuki, K. Ito, T. Abe and Y. Sugiyama Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2). J. Biol. Chem. Vol. 277: 6497-6503( 2002) 55. D. Sugiyama, H. Kusuhara, Y. Shitara, T. Abe and Y. Sugiyama Effect of 17beta-estradiol-D-17beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates Drug Metab. Dispos. Vol. 30: 220-223( 2002) 56. T. Kodawara, S. Masuda, H. Wakasugi, Y. Uwai, T. Futami, H. Saito, T. Abe and K. Inu Organic anion transporter oatp2-mediated interaction between digoxin and amiodarone in the rat liver Pharmaceutical Res. Vol. 19: 738-743( 2002) 57. H. Sakurai, S. Gunji, F. Tokanai, Y. Inoue, T. Maeda and T. Masuda Detection of Photoabsorption Point with Capillary Imaging Gas Proportional Counter IEEE Nucl. Sci. Vol. 49(3): 1560- 1565, 2002. 58. H. Sakurai, S. Gunji, F. Tokanai, T. Maeda, N. Ujiie and N. Saitoh Characteristics of an X-ray Imaging Detecteor with Double Capillary Plates Nucl. Instr. and Meth. A Vol. 513: 282-286(2003) 59. H. Sakurai, S. Gunji, F. Tokanai, T. Maeda, N. Ujiie and N. Saitoh Photoelectron Track Image of Capillary Gas Proportional Counter Nucl. Instr. and Meth. A Vol. 505: 219-222(2003) 60. Unno, M., Abe, T, Onogawa, T., Adachi, H., Ando, T., Ohtsuka, H., Sato, T., Katayose, Y., Suzuki, M. and Matsuno, S. Functional analysis using adenovirus-mediated over-expression of liver-specific organic anion transporter, LST-1/OATP-C/OATP2 and LST-2/OATP8. Hepatology, Vol. 36: 1121 Part 2 Suppl. S, 2002. 61. Adachi, H., Suzuki, T., Abe, M., Asano, N., Mizutamari, H., Tanemoto, M., Nishio, T., Onogawa, T., Toyohara, T., Kasai, S., Satoh, F., Suzuki, M., Tokui, T., Unno, M., Shimosegawa, T., Matsuno, S., Ito, S. and Abe, T. Molecular characterization of human and rat organic anion transporter OATP-D. Am. J. Physiol, Vol. 285: F1188-1197, 2003. 62. Hagiwara, K., Nunoki, K., Ishii, K., Abe, T. and Yanagisawa, T Differential inhibition of the transient outward currents of Kv1.4 and Kv4.3 by endothelin. Biochem. Biophys. Res. Commun, Vol. 310: 634-640, 2003. 63. Tanemoto, M., Abe, T., Obara, N., Abe, M, Satoh, F. and Ito, S. Successful treatment of severe hypertension with combination of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker. Hypertension Res, Vol. 26: 863-868, 2003. 64. Ito, A., Yamaguchi, K., Tomita, H., Suzuki, T, Tohru, O., Sato, T., H., Mikkaichi, T., Nishio, T., Suzuki, T., Unno, M., Sasano, H., Abe, T. and Tamai, M. Distribution of rat organic anion transporting polypeptide -E (oatp-E) in the rat eye. Invest. Ophthalmol. Vis. Sci, Vol. 44: 4877-4884, 2003. 65. Arima, S., Kohagura, K., Xu, H.L., Sugawara, A., Abe, T., Satoh, F., Takeuchi, K. and Ito, S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J. Am. Soc. Nephrol, Vol. 14: 2255-2263, 2003. 66. I. Kuraoka, M. Endou, Y. Yamaguchi, T. Yamada, H. Handa and K. Tanaka Effects of endogeneous DNA base lesions on transcription elongation by mammalian RNA polymerase II. J. Biol. Chem, Vol. 278: 7294-7299, 2003. 67. T. Okada, K. Haze, S. Nadanaka, H. Yoshida, N. G. Seidah, Y. Hirano, R. Sato, M. Negishi and K. Mori A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J. Biol. Chem, Vol. 278: 31024-31032, 2003. 68. R. Kumar, G. S. Krause, H. Yoshida, K. Mori and D. J. DeGracia Dysfunction of the unfolded protein response during global brain ischemia and reperfusion. J. Cereb. Blood Flow Metab, Vol. 23: 462-471, 2003. 69. Unno, M. and Abe, T. Similarity and dissimilarity of LST-1/OATP2/OATP-C (SLC21A6) and OATP8/LST-2 (SLC21A8). J. Gastroenterol, Vol. 38: 108-109, 2003. 70. K. Ishii and U. K. Laemmli Structural and dynamic functions establish chromatin domains. Molecular Cell, Vol. 11: 237-248, 2003. 71. H. Hirai,T. Launey, S. Mikawa, T. Torashima, D. Yanagihara, T. Kasaura, A. Miyamoto and M. Yuzaki New role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neuroscience, Vol. 6: 869-876, 2003. 72. T. Otsuji, E. Okuda-Ashitaka, S. Kojima, H. Akiyama, S. Ito and Y. Ohmiya Monitoring for dynamic biological processing by intra-molecular bioluminescence resonance energy transfersystem using secreted luciferase. Anal. Biochem, Vol. 329: 230-237, 2004. 73. S. Verma, A. M. Shewan, J. A. Scott, F. M. Helwani, N. R. Den Elzen, H. Miki, T. Takenawa and A. S. Yap Arp2/3 activity is necessary for efficient formation of E-cadherin adhesive contacts. Biochem. J, Vol. 279: 34062-34071, 2004. 74. K. Takenaka, H. Nakagawa, S. Miyamoto and H. Miki The pre-mRNA splicing factor SF3a66 functions as a microtuble binding and bundling protein. Biochem. J, Vol. 382: 223-230, 2004. 75. K. Takagaki, T. Satoh, N. Tanuma, K. Masuda, M. Takekawa, H. Shima and K. Kikuchi Characterization of a novel low-molecular-mass dual-specificity phosphatase 3 that enhances activation of JNK and p38. Biochem. J, Vol. 383, 447-455, 2004. 76. Y. L. Wang, A. Takeda, H. Osaka, Y. Hara, A. Furuta, R. Setsuie, Y. J. Sun, J. Kwon, Y. Sato, M. Sakurai, M. Noda, Y. Yoshikawa and K. Wada Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse. Brain Res, Vol. 1019: 1-9. 2004. 77. T. Ono, Y. Kasahara, K. Nakada and J. -I.. Hayashi Presence of interaction but not complementation between human mtDNAs carrying different mutations within a tRNALeu(UUR) gene. Biochem. Biophys. Res. Commun, Vol. 314: 1107-1112, 2004. 78. K. Nakada, A. Sato, H. Sone, A. Kasahara, K. Ikeda, Y. Kagawa, H. Yonekawa and J. -I. Hayashi Accumulation of pathogenic delta-mtDNA induced deafness but not diabetic phenotypes in mito-mice. Biochem. Biophys. Res. Commun, Vol. 323: 175-184, 2004. 79. Y. Funato, T. Terabayashi, N. Suenaga, M. Seiki, T. Takenawa and H. Miki IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res, Vol. 64: 5237-5244, 2004. 80. L. Romero-Ramirez, H. Gao, D. Nelson, E. Hammond, A. H. Lee, H. Yoshida, K. Mori, L. H. Glimcher, N. C. Denko and A. Giaccia XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res, Vol. 64: 5943-5947, 2004. 81. J. Nagai, T. Yazawa, K. Okudera, T. Ito, H. Kigasawa, H. Kitamura and H. Osaka Retinoic acid induce cell death on neuroblastoma cell lines by inhibition of proteasome-dependent degradation of retinoic acid receptor α. Cancer Res, Vol. 64: 7910-7917, 2004. 82. B.H. Jennings, S. Shah, Y. Yamaguchi, M. Seki, R.G. Phillips, H. Handa and D. Ish-Horowics Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. Curr. Biol, Vol. 14: 1680-1684, 2004. 83. H. Chi, B. Ku, M. Takekawa, R. J. Davis and R. A. Flavell GADD45β/GADD45γand MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells. EMBO J, Vo. 23: 1576-1586, 2004. 84. J. Nozaki, H. Kubota, H. Yoshida, M. Naitoh, J. Goji, T. Yoshinaga, K. Mori, A. Koizumi and K. Nagata The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita. Genes Cells, Vol. 9: 261-270, 2004. 85. S..E. Aiyar, J.-L Sun, A..L. Blair, C..A. Moskaluk, Y. Lv, Q.-N. Ye, Y. Yamaguchi, A. Mukherjee, D.-M. Ren, H. Handa and R. Li Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev, Vo.18: 2134-2146, 2004. 86. A. Sato, K. Nakada, H. Shitara, H. Yonekawa and J. -I. Hayashi In vivo Interaction between mitochondria carrying mtDNAs from different mouse species. Genetics, Vol. 167: 1855-1861, 2004. 87. C.-S. Chen, R. Matsuoka, S. Arai, Y. Momiyama, H. Murakami, s.-Y. Kuno, K. Ishikawa, K. Nakada, M. Tawata and J.-I. Hayashi Determination of normal ranges of mitochondial respiratory activties by mtDNA transfer from 54 human subjects to mtDNA-less Hela cells for identification of the pathogenicities of mutated mtDNAs. J. Biochem, Vol. 135: 237-243, 2004. 88. K. Yamamoto, H. Yoshida, K. Kokame, P. J. Kaufman and K. Mori Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J. Biochem, Vol. 136: 343-350, 2004. 89. M. M. Khan, T. Nomura, T. Chiba, K. Tanaka, H. Yoshida, K. Mori and S. Ishii The fusion oncoprotein PML-PAR induces endoplasmic reticulum-associated degradation of N-CoR and ER stress. J. Biol. Chem, Vol. 279: 11814-11824, 2004. 90. N. Inukai, Y. Yamaguchi, I. Kuraoka, T. Yamada, S. Kamijo, J. Kato, K. Tanaka, and H. Handa A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. J. Biol. Chem, Vol. 279: 8190-8195, 2004. 91. Y. Kamei, S. Miura, M. Suzuki, Y. Kai, J. Mizukami, T. Taniguchi, K. Mochida, T. Hata, J. Matsuda, H. Aburatani, I. Nishino and O. Ezaki Skeletal muscle FOXO1(FKHR)-transgenic mice have less skeletal muscle mass, down regulated type I (slow twitch/red muscle) fiber genes. J. Biol. Chem, Vol. 279: 41114-41123, 2004. 92. H. Yoshizaki, Y. Ohba, M. C. Parrini, N. G. Dulyaninova, A. R. Bresnick, N. Mochizuki and M. Matsuda Cell Type-specific Regulation of RhoA Activity during Cytokinesis. J. Biol. Chem, Vol. 279: 44756-44762, 2004. 93. K. Kawamura, K. Takano, S. Suetsugu, S. Kurisu, D. Yamazaki, H. Miki, T. Takenawa and T. Endo N-WASP and WAVE2 acting downstream of phospahtidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor. J. Biol. Chem, Vol. 279: 54862-54871, 2004. 94. N. Takahashi, H. Hatakeyama, H. Okado, A. Miwa, T. Kishimoto, T. Kojima, T. Abe and H. Kasai Sequential exocytosis of insulin granules is associated with redistribution of SNAP25. J. Cell Biol, Vol. 165: 255-262, 2004. 95. C. Miyagi, S. Yamashita, Y. Ohba, H. Yoshizaki, M. Matsuda and T. Hirano STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension. J. Cell Biol, Vol. 166(7): 975-981, 2004. 96. Y. Horie, A. Suzuki, E. Kataoka, T. Sasaki, K. Hamada, J. Sasaki, K. Mizuno and T. Nakano Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J. Clin. Invest, Vol. 113: 1774-1783, 2004. 97. K. Reif, K. Okkenhaug, T. Sasaki, J. Penninger, B. Vanhaesebroeck and J. Cyster Differential roles for phosphoinositide 3-kinase, p110γ and 110δ , in lymphocyte chemotaxis and homoing. J. Immunol, Vol. 173: 2236-2240, 2004. 98. A. Castegna , V.Thongboonkerd,J. Klein, B. C. Lynn, Y. L. Wang, H. Osaka, K. Wada, D. A. Butterfiel Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitincarboxyl-terminal hydrolase L-1, reveals ixidation of key proteins. J. Neurochem, Vol. 88: 1540-1546, 2004. 99. T. Y. Hiyama, E. Watanabe, H. Okado and M. Noda The subfornical organ is the primary locus of sodiu-level sensing by Nax sodium channels for the control of salt-intake behavior. J. Neuroscience, Vol.24: 9276-9281, 2004. 100. K. Kurokawa, ,R.E. Itoh, H. Yoshizaki, Y. Ohba, T. Nakamura, and M. Matsuda Co-activation of Rac1 and Cdc42 at Lamellipodia and Membrane Ruffles Induced by Epidermal Growth Factor. Mol. Biol. Cell, Vol. 15: 1003-1010, 2004. 101. S. Nadanaka, H. Yoshida, F. Kano, M. Murata and K. Mori Activation of mammalian unfolded prorein response is compatible with the quality control system operating in the endoplasmic reticulum. Mol. Biol. Cell, Vol. 15: 2537-2548, 2004. 102. A. Takaya, Y. Ohaba, K. Kurokawa and M. Matsuda RalA Activation at Nascent Lamellipoda of EGF-stimulated Cos7 and Migrating MDCK Cells. Mol. Biol. Cell, Vol. 15: 2549-2557, 2004. 103. M. Bonin, S. Poths, H. Osaka, Y.-L. Wang, K. Wada and O. Riess Microarray expression analysis of gad mice implicates involvement of Parkinson’s disease associated UCH-L1 in multiple metabolic pathways. Mol. Brain Res, Vol. 126: 88-97, 2004. 104. T. Wada, N. Joza, M. Cheng, T. Sasaki, I. Kozieradzki, K. Bachmaier, T. Katada, M. Schreiber, E. Wagner, H. Nishina and J. Penninger MKK7 couples stresss signaling to G2/M cell cycle progression and cellular senescence. Nat. Cell Biol, Vol. 4: 1016-1022, 2004. 105. E. Ainbinder, L. Amir-Zilberstein, Y. Yamaguchi, H. Handa and R. Dikstein Elongation inhibition by DSIF is regulated by the A20 promoter via a novel negative element and NF-κB. Nat. Cell Biol, Vol. 24: 2444-2454, 2004. 106. M. Endou, W. Zhu, J. Hasegawa, H. Watanabe, D..K. Kim, M. Aida, N. Inukai, T. Narita, T. Yamada, A. Furuya, H. Sato, Y. Yamaguchi, S. S. Mandal, D. Reinberg, T. Wada, and H. Handa Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Nat. Cell Biol, Vol. 24: 3324- 3336, 2004. 107. H. Suzuki, D. N. Watkins, K. W. Jair, K. E. Scuebel, S. D. Markowitz, W. D. Chen, T. Pretlow, B. Yang, Y. Akiyama, M. van Engeland, M. Toyaota, T. Kojima, Y. Hinoda, K. Imai, J. G. Herman and S. B. Baylin Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat. Genet, Vol. 36(No.4): 417-422, 2004 108. H. Watanabe, M. Yamazaki, H. Miyazaki, C. Arikawa, K. Itoh, T. Sasaki, T. Maehama, M. Frhoman and Y. Kanaho Phosoholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebeller granule neurons. Neurochem, Vol. 89: 142-151, 2004. 109. H. Sakurai, F. Tokanai, S. Gunji, S. Motegi, H. Toyokawa, M. Suzuki, K. Hirota and S. Kishimoto Measurement of X-ray polarization using optical imaging detector with capillary plate. Nucl. Instr. and Meth.,A, Vol. 525: 6-11, 2004. 110. F. Tokanai, S. Motegi, H. Sakurai, S. Gunji, JI. Suzuki and T. Oku A test of track imaging by cold neutron using optical capillary gas proportional counter. Nucl. Instr. and Meth.,A, Vol. 529: 332-335, 2004. 111. F. Tokanai, H. Sakurai, S. Gunji, S. Motegi, H. Toyokawa, M. Suzuki, K. Hirota, S. Kishimoto and K. Hayashida Hard X-ray polarization measured with a Compton polarimeter at synchrotron radiation facility. Nucl. Instr. and Meth.,A, Vol. 530: 446-452, 2004. 112. A. Satoh, M.Toyota, H. Ikeda, Y. Morimoto, K. Akino, H. Mita, H. Suzuki, Y. Sasaki, T. Kanaseki, Y. Takamura, H. Soejima, T. Urano, K. Yanagihara, T. Endo, Y. Hinoda, M. Fujita, M. Hosokawa, N. Sato, T. Tokino and K. Imai Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-γ-induced HLA-DR expression in colorectal and gastric cancer cells. Oncogene, Vol. 23: 8876-8886, 2004. 113. Mikkaichi, T., Suzuki, T., Onogawa, T., Tanemoto, M., Mizutamari, H., Okada, M., Masuda, S., Tokui, T., Eto, N, Abe, M., Cyaki, T., Unno, M., Hishinuma, T., Inui, K, Ito, S., Goto, J. and Abe, T. Isolation and characterization of novel kidney-specific digoxin transporters. Proc. Natl. Acad. Sci., USA , Vol. 101: 3569-3574, 2004. 114. K. Honda, H. Yanai, T. Mizutani, Negishi, N. Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W. C. Yeh and T. Taniguchi Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc. Natl. Acad. Sci., USA , Vol. 101: 15416-15421, 2004. 115. T. Hirose, Mei-Di Shu and Joan A. Steitz Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay. Proc. Natl. Acad. Sci., USA , Vol. 101: 17976-17981, 2004. 116. 角谷寛 高二酸化炭素・低酸素の自動制御によるマウス睡眠障害システム。 三共生命科学研究財団研究報告書, Vol. 20: 66-71, 2004. 117. M. Takahashi, Y. Kamei and O. Ezaki Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am. J. Physiol, Vol. 288: E117-124, 2005. 118. A. Oda, H. Miki,, I. Wada, H. Yamaguchi, D. Yamazaki, S. Suetsugu, M. Nakajima, A. Nakayama, K. Okawa, H. Miyazaki, K. Matsuno, H. D. Ochs, L. M. Machesky, H. Fujita and Takenawa, T. WAVE/Scars in Platelets. Blood, Vol. 105: 3141-3148, 2005. 119. M. Murai, M, Toyota, A. Satoh, H. Suzuki, K. Akino, H. Mita, T. Ishida, L. Shen, G. Garcia-Manero, J-PJ Issa, Y. Hinoda, T. Tokino and K. Imai Aberrant methylation and silencing of the BNIP3 gene in hematopietic tumors. British J. Cancer, Vol. 92: 1165-1172, 2005. 120. M. Murai, M.Toyota, H. Suzuki, A. Satoh, Y. Sasaki, K. Akino, M. Ueno, F. Takahashi, M. Kusano, H. Mita, K. Yanagihara, T. Endo, Y. Hinoda, T. Tokino and K. Imai Aberrant methylation and silencing of BNIP3 gene in colorectal and gastric cancer. Clin. Cancer Res, Vol. 11: 1021-1027, 2005. 121. Y. Seki, K. Hayashi, K. Itoh, M. Mizugaki, M. Saitou and Y. Matsui Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Devel. Biol, Vol. 278: 440-458, 2005. 122. H. Hirai, T. Miyazaki, W. Kakegawa, S. Matsuda, M. Mishina, M. Watanabe and M. Yuzaki Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes. EMBO Reorts, Vol. 6: 90-95, 2005. 123. Y. Tsuchiya, I. Minami, H. Kadotani and E. Nishida Resetting of peripheral circadian clock by prostaglandin E2. EMBO Reorts, Vol.6: 256-261, 2005. 124. M. Hirabayashi, D. Ijiri, Y. Kamei, A. Tajima and Y. Kanai Transformation of skeletal muscle from fast to slow-twitch during acquisition of cold tolerance in the chick. Endocrinol, Vol. 146: 399-405, 2005. 125. K. Akino, M. Toyota, H. Suzuki, H. Mita, Y. Sasaki, M. Ohe-Toyota, Jean-Pierre J Issa, Y. Hinoda, T. Tokino and K. Imai. The RAS effector RASSF2 is a novel tumor suppressor in colorectal cancer. Gastroenterology, Vol. 129: 156-169, 2005. 126. H. Yamaguchi, M. Lorenz, S. Kenpiak, C. Sarmiento, S. Coniglio, M. Symons, J. Segall, R. Eddy, H. Miki, T. Takenawa and J. Condeelis Molecular mechanisms of invadopodium formation: the role of N-WASP-Arp2/3 complex pathway and cofilin. J. Cell Biol, Vol. 168: 441-452, 2005. 127. H. Bierne, H. Miki, M. Innocenti, G. Scita, F. B. Gertler, T.Takenawa, T., and P. Cossart WASP-related proteins Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. J. Cell Sci, Vol.: 118: 1537-1547, 2005. 128. K. Kasai, M. Ohara-Imaizumi, N. Takahashi, S. Mizutani, S. Zhao, T. Kikuta, H. Kasai, S. Nagamatsu, H. Gomi and T. Izumi Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. J. Clin. Invest, Vol. 115(2): 388-396, 2005. 129. Y. Manago, Y. Kanahori, A. Shimada, A. Sato, T. Amano, Y. Sato-Sano, R. Setsuie, M. Sakurai, S. Aoki, Y. L. Wang, H. Osaka, K. Wada and M. Noda Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase L1. J. Neurochem, Vol. 92: 1061-1072, 2005. 130. K. Niisato, A. Fujikawa, S. Komai, T. Shintani, E. Watanabe, G. Sakaguchi, G. Katsuura, T. Watanabe and M. Noda Age-dependent enhancement of hippocampal long-term potentiation and impairment of spatial learning through the Rho-associated kinase pathway in protein tyrosine phosphatase receptor type Z-deficient mice. J. Neurosci, Vol. 25: 1081-1088, 2005. 131. M. Yoshizawa, M. Sone, T. Kawauchi, Y. V. Nishimura, M. Terao, K. Chihama, Y. Nabeshima and M. Hoshino Involvement of a Rac activator, P-Pex1, in neurotrophin-derived signaling and neuronal migration. J. Neurosci, Vol. 25: 4406-4419, 2005. 132. Y. Kamei, M. Suzuki, H. Miyazaki, N. Tsuboyama-Kasaoka, J. Wu, Y. Ishimi and O. Ezaki Ovariectomy in mice decreases lipid metabolism -related gene expression in adipose tissue and skeletal muscle with increased body fat. J. Nutr. Sci. Vitaminol, Vol 51. :110-117, 2005. 133. S. Saitoh, K. Ishii, Y. Kobayashi and K. Takahashi Spindle checkpoint signaling requires the Mis6 kinetochore　subcomplex, which interacts with Mad2 and mitotic spindles. Molecular Biology of the Cell, Vol. 16: 3666-3677, 2005. 134. Y.Kubo, S. Sekiya, M. Ohigashi, C. Takenaka, K. Tamura, S. Nada, T. Nishi, A. Yamamoto and A. Yamaguchi ABCA5 resides in lysosomes, and ABCA5 knockout mice develop lysosomal disease-like symptoms. Molecular and Cellular Biology, Vol. 25: 4138-4149, 2005. 135. G. Wang, M.A. Balamotis, J.L. Stevens, Y. Yamaguchi, H. Handa and A. Berk Mediator requirement for both recruitment and post-recruitment steps in transcription initiation. Mol. Cell, Vol. 17: 683-694, 2005. 136. M. Takekawa, K. Tatebayashi and H. Saito Conserved docking site essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. Mol. Cell, Vol. 18, 295-306, 2005. 137. Y. Ohinata, B. Payer, D. O'Carroll, K. Ancelin, Y. Ono, M. Sano, S. C. Barton, T. Obukhanych, M. Nussenzweig, A. Tarakhovsky, M. Saitou & M. A. Surani Blimp-1 is a critical determinant of the germ cell lineage in mice. Nature, Vol. 436: 207-213, 2005. 138. A. Takaoka,H. Yanai, S. Kondo, G. Duncan, H. Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. Mak, and T. Taniguchi Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature, Vol. 434: 243-249, 2005. 139. K. Honda, Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya and T. Taniguchi Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-1 interferon induction. Nature, Vol. 434: 1035-1040, 2005. 140. K. Honda, H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida and T. Taniguchi IRF-7 is the master regulator of type-1 interferon-dependent immune response. Nature, Vol. 434: 772-777, 2005. 141. M. Hoshino, S. Nakamura, K. Mmori, T. Kawauchi, M. Terao, Y. V. Nishimura, A. Fukuda, Y. Fuse, N. Matsuo, M. Sone, M. Watanabe, H. Bito, T. Terashima, C. V. E. Wright, Y. Kawaguchi, K. Nakao and Y. Nabeshima Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron, Vol. 47: 201-213, 2005. 142. C.H. Wu, C. Lee, R. Fan, M.J. Smith, Y. Yamaguchi, H. Handa and D.S. Gilmour Molecular characterization of Drosophila NELF. Nucleic Acids Res. Vol. 33: 1269-1279, 2005. 143. Y. Makino, H. Nakamura, E. Ikeda, K. Ohnuma, K. Yamauchi, Y. Yabe, L. Poellinger, Y. Okada, C. Morimoto and H. Tanaka Hypoxia-inducble factor regulates survival of antigen receptor-driven T cells. J. Immunol. Vol. 171: 6534-6540, 2003. 144. H. Nakamura, Y. Makino, K. Okamoto, L. Poellinger, K. Ohnuma, C. Morimoto and H. Tanaka TCR-engagement increases HIF-1a protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells. J. Immunol. Vol. 174: 7592-7599, 2005. 145. T. Kodama, N. Shimizu, N. Yoshikawa, Y. Makino, R. Ouchida, K. Okamoto, T. Hisada, H. Nakamura, C. Morimoto and H. Tanaka Role of the glucocorticoid receptor for regulation of hypoxia-dependent geen expression. J. Biol. Chem. Vol. 278: 33384-33391, 2003. 146. M. Matsumoto, Y. Makino, T. Tanaka, H. Tanaka, N. Ishizaka, E. Noiri, T. Fujita and M. Nangaku Induction of Renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats. J. Am. Soc. Nephrol. Vol. 14: 1825-1832, 2003. 147. H. Ameln, T. Gustafsson, C. J. Sundberg, L. Poellinger, E. Jansson, and Y. Makino Physiological activation of hypoxia-inducible factor-1 in human skeletal muscle. FASEB J. Vol. 19: 1009-1011, 2005. 148. H. Kasai, H. Hatakeyama, T. Kishimoto, T. T. Liu, T. Nemoto and N. Takahashi. A new quantitative (TEPIQ) analysis of exocytosis based on two-photon excitation imaging. J. Physiology , Vol. 568: 891-903, 2005. 149. T. Kishimoto, T.T. Liu, H. Hatakeyama, T. Nemoto, N. Takahashi and H. Kasai. Sequential compound exocytosis of large dense-core vesicles in PC12 cells studied with TEPIQ analysis. J. Physiology , Vol. 568: 905-915, 2005. 150. T.T. Liu, T. Kishimoto, H. Hatakeyama, T. Nemoto, N. Takahashi　and H. Kasai. Exocytosis and endocytosis of small vesicle in PC12 cells studied with TEPIQ analysis. J. Physiology , Vol. 568: 917-929, 2005. 151. Y. Ozaki, K. Kontani, J. Hanaoka, T. Chano T, K. Teramoto, N. Tezyka, S. Sawai, S. Fujino, T. Yoshiki, H. Okabe and H. Ohkubo Expression and immunogenicity of a tumor-associated antigen, 90K/Mac-2 binding protein, in lung carcinoma. Cancer , Vol. 95: 1954-1962, 2002. 152. A. Isshiki, K. Ohtani, M. Kyo, H. Yamamoto and K. Akimitsu Green fluorescent detection of fungal colonization and endopolygalacturonase gene expression in the interaction of Alternaria citri with citrus. Phytopathology ,Vol. 93: 768-773, 2003. 153. L.W. Timmer, T.L. Peever, Z. Dolel and K. Akimitsu Alternaria diseases of citrus: novel pathosystems. Phytopathologia Mediterranea ,Vol. 42: 99-112, 2003. 154. K. Akimitsu., K. Ohtani and H. Yamamoto Mitochondrial gene controlling toxin sensitivity and specificity in plant and fungus interaction. Proceeding of 2003 International Symposium of Korean Society of Agricultural Chemistry and Biotechnology ,p61-68, 2003. 155. K. Gomi, Y. Yamasaki, H. Yamamoto and K. Akimitsu Characterization of a hydroperoxide lyase gene and effect of C6-volatiles on expression of genes of the oxylipin metabolism in Citrus. Journal of Plant Physiology ,Vol. 160: 1219-1231, 2003. 156. K. Ohtani, A. Isshiki, H. Katoh, H. Yamamoto and K. Akimitsu Involvement of carbon catabolite repression on regulation of endopolygalacturonase gene expression in citrus fruit, Journal of General Plant Pathology ,Vol. 69: 120-125, 2003. 157. K. Gomi, H. Yamamoto and K. Akimitsu Epoxide hydrolase: A mRNA induced by a fungal pathogen Alternaria alternata on rough lemon (Citrus jambhiri Lush). Plant Molecular Biology ,Vol. 53: 189-199, 2003. 158. K. Akimitsu, T.L. Peever and L.W. Timmer Molecular, ecological and evolutionary approaches to understanding Alternaria diseases of citrus. Molecular Plant Pathology ,Vol. 4: 435-446, 2003. 159. K. Teramoto, T. Chano, Y. Ozaki et al. Expression of RB1CC1, a novel tumor suppressor gene, is inversely correlated with the Ki-67 proliferation index in primary breast cancers. Cancer Therapy ,Vol. 1: 103-107. 2003. 160. K. Kontani, T. Chano, Y. Ozaki, N. Tezuka, S. Sawai, S. Fujino, Y. Saeki and H. Okabe RB1CC1 suppresses cell cycle progression through RB1 expression in human neoplastic cells. Int. J. Mol. Med ,Vol. 12: 767-769, 2003. 161. T. Ushiyama, T. Chano, K. Inoue and Y. Matsusue Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids. Ann. Rheum. Dis ,Vol. 62: 108-112, 2003. 162. K. Mori, T. Chano, T. Ikeda, S. Ikegawa, Y. Matsusue, H. Okabe and Y. Saeki Decrease in serum nucleotide pyrophosphatase activity in ankylosing spondylitis. Rheumatology ,Vol. 42: 62-65, 2003 163. S. Kamiyama, T. Suda, R. Ueda, M. Suzuki, R. Okubo, N. Kikuchi, Y. Chiba, S. Goto, H. Toyoda, K. Saigo, M. Watanabe, H. Narimatsu, Y. Jigami and S. Nishihara Molecular cloning and identification of 3'-phosphoadenosine 5'-phosphosulfate transporte. J. Biol. Chem ,Vol. 278: 25958-25963, 2003. 164. H. Barth, C. Schafer, M.I. Adah, F. Zhang, R.J. Linhardt, H. Toyoda, A. Kinoshita-Toyoda, T. Toida, T.H. Van Kuppevelt, E. Depla, F. Von Weizsacker, H.E. Blum and T.F. Baumert Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate J. Biol. Chem ,Vol. 278: 41003-41012, 2003. 165. H. Morio, Y. Honda, H. Toyoda, M. Nakajima, H. Kurosawa and T. Shirasawa EXT gene family member rib-2 is essential for embryonic development and heparan sulfate biosynthesis in Caenorhabditis elegans. Biochem. Biophys. Res. Commun ,Vol. 301: 317-323, 2003. 166. H. Hirai,T. Launey, S. Mikawa, T. Torashima, D. Yanagihara, T. Kasaura, A. Miyamoto and M. Yuzaki New role of δ2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neuroscience ,Vol. 6: 869-876, 2003. 167. K. Ito, T. Tanaka, R. Hatta, M. Yamamoto, K. Akimitsu and T. Tsuge Dissection of the host range of the fungal plant pathogen Alternaria alternata by modification of the secondary metabolism. Molecular Microbiology ,Vol. 52: 399-411, 2004. 168. K. Akimitsu, K. Ohtani, K. Gomi, S. Nalumpang, Y. Yamasaki, A. Masunaka and H. Yamamoto A role of host-selective toxin for controlling citrus defense systems against Alternaria pathogens. Botanica ,Vol. 54: 1-11, 2004. 169. K. Ohtani, A. Masunaka, Y. Yamasaki, H. Yamamoto and K. Akimitsu Tailor-made toxin target controlling the specificity of ACR-toxin. In Biology of Molecular Plant-Microbe Interactions, Volume 4, (Lugtenberg B. et al. ed.; APS Press) ,ｐ154-157, 2004. 170. K. Akimitsu, A. Isshiki, K. Ohtani, H. Yamamoto, D. Eshel and D. Prusky Sugars and pH: A clue to the regulation of fungal cell wall-degrading enzymes in plants. Physiological and Molecular Plant Pathology ,Vol. 65: 271-275, 2004. 171. T. Chano, K. Mori, K. Scotlandi, S. Benini, C, Lapucci, M.C. Manara, M. Serra, P. Picci, H. Okabe and N. Baldini Differentially expressed genes in multidrug resistant variants of U-2 OS human osteosarcoma cells. Oncol. Rep ,Vol. 11: 1257-1263, 2004. 172. N. Bamba, T. Chano, T. Taga, S. Ohta, Y. Takeuchi and H. Okabe Expression and regulation of RB1CC1 in developing murine and human tissues. Int. J. Mol. Med ,Vol. 14: 583-587, 2004. 173. K. Mori, H. Kizawa, T. Ushiyama, T. Chano, H. Inoue, N. Tsuchiya, H. Okabe, Y. Matsusue and S. Ikegawa Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese males. Am. J. Med. Genet. A ,Vol. 130: 169-471, 2004. 174. K. Mori, T. Chano, K. Matsumoto, M. Ishizawa, Y. Matsusue and H. Okabe Type-selective muscular degeneration promotes infiltrative growth of intramuscular lipoma. BMC Musculoskelet Disord. (Review) ,Vol. 5: 20, 2004. 175. K. Mori, T. Chano, K. Yamamoto, Y. Matsusue and H. Okabe Expression of macrophage inflammatory protein-1alpha in Schwann cell tumors. Neuropathology ,Vol. 24: 131-135, 2004. 176. M. Serra, G. Reverter-Branchat, D. Maurici, S. Benini, J.N. Shen, T. Chano, C.M. Hattinge, M.C. Manara, M. Pasello, K. Scotlandi and P. Picci Analysis of dihydrofolate reductase and reduced folate carrier gene status in relation to methotrexate resistance in osteosarcoma cells. Ann. Oncol ,Vol. 15: 151-160, 2004. 177. S. Nishihara, R. Ueda, S. Goto, H. Toyoda, H. Ishida and M. Nakamura Approach for functional analysis of glycan using RNA interference. Glycoconj. J ,Vol. 21: 63-68, 2004. 178. T. Tsuchiya, T. Osanai, A. Ogose, G. Tamura, T. Chano, Y. Kaneko, A. Ishikawa, H. Orui, T. Wada, T. Ikeda, M. Namba, M. Takigawa, H. Kawashima, H. Hotta, A. Tsuchiya, T. Ogino and T. Motoyama Methylation status of EXT1 and EXT2 promoters and two mutations of EXT2 in chondrosarcoma. Cancer Genet. Cytogenet ,Vol. 158: 148-155, 2005 179. K. Ogi, M. Toyota, H. Mita, A. Satoh, L. Kashima, Y. Sasaki, H. Suzuki, K. Akino, N. Nishikawa, M. Noguchi, Y. Shinomura, K. Imai, H. Hiratsuka and T. Tokino Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtubule inhibitors. Cancer Biology & Therapy. Vol. 4: 773-780, 2005, 180. Watanabe R, Chano T, Inoue H, Isono T, Koiwai O, Okabe H. RB1CC1 is critical for myoblast differentiation through Rb1 regulation. Virchows Arch. Vol. 447(3): 643-648, 2005. 181. H. Yano, M. Yamamoto-Hino, M. Abe, R. Kuwahara, S. Haraguchi, I. Kusaka, W. Awano,A. Kinoshita-Toyoda, H. Toyoda, and S. Goto Distinct functional units of the Golgi complex in Drosophila cells. Proc. Natl. Acad. Sci. USA ,Vol. 102: 13467-13472, 2005. 182. H. Negishi, Y. Ohba, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi and K. Honda Negative regulation of Toll-like receptor signaling by IRF-4. Proc. Natl. Acad. Sci. U.S.A. Vol. 102: 15989-15994, 2005. 183. Z. M. Huang, T. Tan, H. Yoshida, K. Mori, Y. Ma and T. S. Yen Activation of hepatitis B virus S promoter by a cell type-restricted IRE1-dependent pathway induced by endoplasmic reticulum stress. Molecular and Cellular Biology ,Vol. 25: 7522-7533, 2005. 184. A. Masunaka, K. Ohtani, T.L. Peever, L.W. Timmer, T. Tsuge, M. Yamamoto, H. Yamamoto and K. Akimitsu An isolate of Alternaria alternata that is pathogenic to both tangerines and rough lemon and produces two host-selective toxins, ACT- and ACR-toxins. Phytopathology ,Vol. 95, 241-247, 2005. 185. Y.W. Ha, B.T. Jeon, S.H. Moon, H. Toyoda, T. Toida, R.J. Linhardt and Y.S. Kim Characterization of heparan sulfate from the unossified antler of Cervus elaphus. Carbohydr. Res. Vol. 340: 411-416, 2005. 186. P. Vongchan, M. Warda, H. Toyoda, T. Toida, R.M. Marks and R.J. Linhardt Structural characterization of human liver heparan sulfate. Biochim. Biophys. Acta ,Vol. 1721: 1-8, 2005. 187. J. Sasaki, T. Sasaki, M. Yamazaki, K. Matsuoka, C. Taya, H. Shitara, S. Takasuga, M. Nishio, K. Mizuno, T. Wada, H. Miyazaki, H. Watanabe, R. Iizuka, S. Kubo, S. Murata, T. Chiba, T. Maehama, K. Hamada, H. Kishimoto, M. A. Frohman, K. Tanaka, J. M. Penninger, H. Yonekawa, A. Suzuki and Y. Kanaho Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I α. J. Exp. Med. Vol. 201: 276-287, 2005. 188. Y. Hirano, K. B. Hendil, H. Yashiroda, S. Iemura, R. Nagane, Y. Hioki, T. Natsume, K. Tanaka and S. Murata A heterodimeric complex that promotes the assembly of mammalian 20S proteasome. Nature ,Vol. 437: 1381-1385, 2005. 189. H. Fujimoto, N. Kato, M. Takekawa, Xiao Zhou Xu, A. Kosugi, T. Kondo, M. Imamura, I. Oishi, A. Yoda and Y. Minami Regulation of the anti-oncogenic Chk2 kinase by the oncogenic Wip1 phosphatase. Cell Death Differ.（2005/11/25 on line） 190. H. Hirai, Zhen Pang, Dashi Bao, T, Miyazaki, Leyi Li, E. Miura, J. Parris, Yongqi Rong, M. Watanabe, M. Yuzaki and J. Morgan Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nature Neuroscience , Vol. 8: 1534-1541, 2005. 191. T. Yamada, Y. Yamaguchi, N. Inukai, S. Kamijo, T. Mura and H. Handa (*equal contribution) P-TEFb-Mediated Phosphorylation of hSpt5 C-Terminal Repeats is Critical for Processive Transcription Elongation. Mol. Cell , Vol. 21: 227-237, 2006. 192. Y. Oda, T. Okada, H. Yoshida, R. J. Kaufman, K. Nagata and K. Mori Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. Journal of Cell Biology ,Vol. 172: 383-393, 2006. 193. S. Tsukuda, K. Gomi, H. Yamamoto and K. Akimitsu Characterization of cDNAs encoding two distinct miraculin-like proteins and stress-related modulation of the corresponding mRNAs in Citrus jambhiri Lush. Plant Molecular Biology ,Vol. 60: 125-136, 2006. 194. E. Okuda-Ashitaka, T. Minami, S. Matsumura, H. Takeshima, R. K. Reinscheid, O. Civelli and S. Ito The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury. Eur. J. Neurosci. Vol. 23: 995-1004, 2006. 195. A. Miura, K. Yamagata, M. Kakei, H. Hatakeyama, N. Takahashi, K. Fukui, T. Nammo, K. Yoneda, Y. Inoue, F.M. Sladek, M.A. Magnuson, H. Kasai, J. Miyagawa, F.J. Gonzalez and I. Shimomura Hepatocyte nuclear factor-4a is essential for glucose-stimulated insulin secretion by pancreatic b-cells. J. Biol. Chem. Vol. 281: 5246-5257, 2006. 196. H. Hatakeyama, T. Kishimoto, T. Nemoto, H. Kasai and N. Takahashi Rapid glucose sensing by protein kinase A for insulin exocytosis in pancreatic islets. J. Physiol , Vol. 570: 271-282, 2006. 197. Qingyu Qin, R. Inatome, A. Hotta, M. Kojima, H. Yamamura, H. Hirai, T. Yosｈizawa, H. Tanaka, K. Fukami and S. Yanagi A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expamded polyglutamine protein. J.C.B. Vol. 172: 497-504, 2006. 198. E. Watanabe, T.Y. Hiyama, H. Shimizu, R. Kodama, N. Hayashi, S. Miyata, Y. Yanagawa, K. Obata and M. Noda Sodium-level-sensitive sodium channel Nax is expressed in glial laminate processes in the sensory circumventricular organs. American Journal of Physiology ,Vol. 290: R568-576, 2006. 199. K. Terasawa, M. Toyota, S. Sagae, K. Ogi, H. Suzuki, T. Sonoda, K. Akino, R. Maruyama, N. Nishikawa, K. Imai, Y. Shinomura, T. Saito and T. Tokino Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. British J. Cancer ,Vol. 94: 914-921, 2006. 200. R. Maruyama, F. Aoki, M. Toyata, Y. Sasaki, H. Akashi, H. Mita, H. Suzuki, K. Akino, M. Ohe-Toyota, Y. Maruyama, H. Tatsumi, K. Imai, Y. Shinomura and T. Tokino Comparative genome analysis identifies the vitamin D receptor as a direct target of p53-mediated transcriptional activation. Cancer Res. Vol. 66: 4574-4583, 2006. 201. Y. Funato, T. Michiue, M. Asashima and H, Miki The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt/b-catenin signaling through Dishevelled. Nature Cell Biology ,Vol. 8: 501-508, 2006. 202. Y. Kamei , H. Lwin, K. Saito, T. Yokoyama, N. Yoshikawa, O. Ezaki and H. Tanaka The 2.3 genotype of ESRRA23, a 23-bp sequence in the 5’-flanking region of the ERR1 gene, is associated with a higher body mass index than the 2.2 genotype. Obesity Research ,Vol. 13: 1843-1844, 2005. 203. M. Komatsu, S. Waguri, T. Ueno, J. Iwata, S. Murata, I. Tanida, J. Ezaki, N. Mizushima, Y. Ohsumi, Y. Uchiyama, E. Kominami, K. Tanaka and T. Chiba Impairment of starvation-induced and consitutive autophagy in Atg7-deficient mice. J. Cell Biol ,Vol. 169: 425-434, 2005. 204. M. Zhang, C. Obata, H. Hisaeda, K. Ishii, S. Murata, T. Chiba, K. Tanaka, Y. Li, M. Furue, B. Chou, T. Imai, X. Duan and K. Himeno A novel DNA vaccine based on ubiquitin-proteasome pathway targeting 'self'-antigens expressed in melanoma/melanocyte. Gene Ther ,Vol. 12: 1049-1057, 2005. 205. X. Duan, H. Hisaeda, J. Shen, L. Tu, T. Imai, B. Chou, S. Murata, T. Chiba, K. Tanaka, H. J. Fehling, T. Koga, K. Sueishi and K. Himeno The ubiqutin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+T cells. Int. Immunol ,Vol. 18: 679-687, 2006. 206. K. Ishii, H. Hisaeda, X. Duan, T. Imai, T. Sakai, H.J. Fehling, S. Murata, T. Chiba, K. Tanaka, S. Hamano, M. Sano, A. Yano and K. Himeno The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1. Microbe Infect ,Vol. 8: 1045-1053, 2006. 207. M. Komatsu, S. Waguri, T. Chiba, S. Murata, J. Iawta, I. Tanida, T. Ueno, M. Koike, Y. Uchiyama, E. Kominami and K. Tanaka Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature ,Vol. 441: 880-884, 2006. 208. Mikkaichi, T., Suzuki, T., Tanemoto, M., Ito, S. and Abe, T. The organic anion transporter(OATP) family. Drug Metab. Pharmacokinet.. Vol. 19:171-179, 2004 209. S. Koizume, S. Takizawa, K. Fujita, N. Aida, S. Yamashita, Y. Miyagi and H. Osaka Aberrant trafficking of a proteolipid protein in a mild Pelizaeus-Merzbacher disease. Neuroscience Vol. 141: 1861-1869, 2006 210. 福原俊一、竹上未紗、鈴鴨よしみ、陳和夫、井上雄一、角谷寛、岡靖哲、野口裕之、脇田貴文、並河努、中島敬哉、三嶋理晃、Murray W. Johns 日本語版The Epworth Sleepiness Scale(JESS)−これまで使用されていた多くの「日本語版」との主な差異と改訂− 日呼吸会誌 Vol. 44: 896-898, 2006 211. H. Yano, M. Yamamoto-Hino, M. Abe, R. Kuwahara, S. Haraguchi, A. Toyoda and S. Goto Distinct functional blocks of the Golgi complex in Drosophila cells. Proc. Natl. Acad. Sci. USA Vol. 102: 13467-13472, 2005 212. K. Hamada, T. Sasaki, P. Koni, M. Natsui, H. Kishimoto, J. Sasaki, N. Yajima, Y. Horie, G. Hasegawa,M. Naito,J. Miyazaki, T. Suda, H. Itoh, K. Nakao, T. Mak, T. Nakano & A. Suzuki The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes & Dev. Vol. 19, 2054-2065, 2005 213. M. Zhao, B. Song, J. Pu, T. Wada, B. Reid, G. Tai, F. Wang, A. Guo,P. Walczysko, Y. Gu, T. Sasaki, A. Suzuki, J. Forrester, H. Bourne, P. Devreotes, C. McCaig & J. Penninger Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN. Nature Vol. 442: 457-460, 2006 214. J. Ferguson, L. Milne, S. Kulkarni, T. Sasaki, S. Walker, S. Andrews, T. Crabbe, P. Finan, G. Jones, S. Jackson, M. Camps, C. Rommel, M. Wymann, E. Hirsch, P. Hawkins & L. Stephens PI(3)Kγ has an important, context-dependent role in neutrophil chemokinesis. Nature Cell Biol. Vol. 9: 86-91, 2007 215. M. Nishio, K. Watanabe, J. Sasaki, C. Taya, S. Takasuga, R. Iizuka, T. Balla, M. Yamazaki, H. Watanabe, R. Itoh, S. Kuroda, Y. Horie, I. F?rster, T. Mak, H. Yonekawa, J. Penninger, Y. Kanaho, A. Suzuki A. & T. Sasaki Control of cell polarity and motility by the PI(3,4,5)P3 phosphatase SHIP1. Nature Cell Biol. Vol. 9: 36-44, 2007 216. F. Tokanai, T. Atsumi, T. Endo, Y. Fujita, Y. Ohishi, T. Okada, H. Sakurai, S. Gunji, S. Kishimoto Developments of optical imaging capillary plate gas detector Nucl. Instr. and Meth.,A Vol. 567: 376-380, 2006 217. A. Sato, K. Nakada, M. Akimoto, K. Ishikawa, T. Ono, H. Shitara, H. Yonekawa and J. -I. Hayashi Rare creation of recombinant mtDNA halotypes in mammalian tissues. Proc. Natl. Acad. Sci. USA Vol. 102: 6057-6062, 2005 218. A. Sato, K. Kono, K. Nakada, K. Ishikawa, S.-I. Inoue, H. Yonekawa and J.-I. Hayashi Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation. Proc. Natl. Acad. Sci. USA Vol. 102: 16765-16770, 2005 219. K. Nakada, A. Sato, K. Yoshida, T. Morita, H. Tanaka, S.-I Inoue, H. Yonekawa and J.-I. Hayashi Mitochondoria-related male infertility. Proc. Natl. Acad. Sci. USA Vol. 103: 15148-15153, 2006 220. H. Yoshida, S. Nadanaka R. Sato and K. Mori XBP1 is critical to protect cells from endoplasmic reticulum stress: Evidence from site-2 protease-deficient Chinese hamster ovary cells. Cell Struct. Funct. Vol. 31: 17-125, 2006 221. Kishimoto T., Kimura R., Liu T.T., Nemoto T., Takahashi N., Kasai H. Vacuolar sequential exocytosis of large dense-core vesicles in adrenal medulla. EMBO J. Vol. 25: 673-682, 2006 222. K. Fukui, Q. Yang, Y. Cao, N. Takahashi, H. Hatakeyama, H. Wang, J. Wada, Y. Zhang, L. Marselli, T. Nammo, K. Yoneda, M. Onishi, S. Higashiyama, Matsuzawa, F. J. Gonzalez, G. C. Weir, H. Kasai, Y., I. Shimomura, J. Miyagawa, C. B. Wollheim, and K. Yamagata The HNF-1 Target Collectrin controls insulin exocytosis by SNARE complex formation. Cell Metabolism Vol. 2(6): 373-384, 2005 223. Chano T, Saji M, Inoue H, et al. Neuromuscular abundance of RB1CC1 contributes the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation. Int. J. Mol. Med. Vol. 18: 425-432, 2006 224. Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K. Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma. Hum Mol Genet. Vol. 15(6): 821-30, 2006 225. E. Goda, S. Kamiyama, T. Uno, H. Yoshida, M. Ueyama, A. Kinoshita-Toyoda, H. Toyoda, R. Ueda and S. Nishihara Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phsphosulfate transporter. J. Biol. Chem. Vol. 281: 28508-28517, 2006 226. T. Torashima, S. Okoyama, T. Nishizaki and H. Hirai In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectors Brain Research Vol. 1082(1): 11-22, 2006 227. T. Torashima, S. Okoyama, T. Nishizaki and H. Hirai Exposure of lentiviral vectors to subneutral pH shifts the tropism from Purkinje cell to Bergmann glia. European Journal of Neuroscience Vol. 24: 371-380, 2006 228. Nakanishi T, Kubota H, Ishibashi N, Kumagai S, Watanabe H, Yamashita M, Kashiwabara S, Miyado K, Baba T. Possible role of mouse poly(A) polymerase mGLD-2 during oocyte maturation. Developmental Biology. Vol. 289: 115-126, 2006 229. Takeda Y, Tachibana I, Miyado K, Kobayashi M, Miyazaki T, Funakoshi T, Kimura H, Yamane H, Saito Y, Goto H, Yoneda T, Yoshida M, Kumagai T, Osaki T, Hayashi S, Kawase I, Mekada E Tetraspanins CD9 and CD81 function to prevent the fusion of blood mononuclear phagocytes. J Cell Biol. Vol. 161: 945-956, 2003 230. Ishibashi T, Ding L, Ikenaka K, Inoue Y, Miyado K, Mekada E, Baba H Tetraspanin protein CD9 is a novel paranodal component regulating paranodal junctional formation. J Neurosci. Vol. 24: 96-102, 2004 231. Schulzke, J. D., Gitter, A. H., Mankertz, J., Spiegel, S., Seidler, U., Amasheh, S., Saitou, M., Tsukita, S., and Fromm, M. Epithelial transport and barrier function in occludin-deficient mice. Biochim. Biophys. Acta Vol. 1669, 34-42, 2005 232. Seki, Y., Hayashi, K., Itoh, K., Mizugaki, M., Saitou, M., and Matsui, Y. Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Dev. Biol. Vol. 278: 440-458, 2005 233. Western, P., Maldonado-Saldivia, J., van den Bergen, J., Hajkova, P., Saitou, M., Barton, S., and Surani, M. A. Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2, and differences between human pluripotent cell lines. Stem Cells Vol. 23, 1436-1442, 2005 234. *Saitou, M., Payer, B., O’Carroll, D., Ohinata, Y., and *Surani, M. A. Blimp1 and the emergence of the germ line during development in the mouse. Cell Cycle Vol. 4, 1736-1740, 2005 235. Payer, B., Chuva de Sousa Lopes, S. M., Barton, S. C., Lee, C., Saitou, M., and Surani, M. A. Generation of stella-GFP transgenic mice, a novel tool to study germ cell development. Genesis Vol. 44, 75-83, 2006. 236. Kurimoto, K., Yabuta, Y., Ohinata, Y., Ono, Y., Uno, D. K., Yamada, R. G., Ueda, H. R., and Saitou, M. An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis. Nuc. Acids Res. Vol. 34, e42, 2006. 237. Yabuta, Y., Kurimoto, K., Ohinata, Y., Seki, Y., and Saitou, M. Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling. Biol. Reprod. Vol. 75, 705-716, 2006. 238. Horsley, V., O’Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., and Fuchs, E. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell Vol. 126, 587-609, 2006. 239. M. Shirane and K. Nakayama Protrudin induces neurite formation by directional membrane trafficking. Science Vol. 314: 818-821, 2006. 240. Wang, H. Q., Nakaya, Y., Du, Z., Yamane, T., Shirane, M., Kudo, T., Takeda, M., Takebayashi, K., Noda, Y., Nakayama, K. I., Nishimura, M. Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum. Mol. Genet. Vol. 14: 1889-1902, 2005. 241. K. Akino, M. Toyota, H. Suzuki, T. Imai, R. Maruyama, M. Kusano, N. Nishikawa, Y. Watanabe, Y. Sasaki, T. Abe, E. Yamamoto, I. Terasawa, T. Sonoda, M. Mori, K. Imai, Y. Shinomura and T. Tokino. Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer. Cancer Sci. Vol. 98: 88-95, 2007. 242. Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and an association with Epstein-Barr virus. Cancer Vol. 106, 1467-1479 (2006) 243. Sahin, U., Weskamp, G., Zhou, H., Higashiyama, S., Peschon, J., Hartmann, D., Safting, P. and Blobel, C.P. Distinct roles for ADAM10 and 17 in ectodomain shedding of six EGFR-ligands. J. Cell Biol. Vol. 164：769-779, 2004. 244. Tanaka, M., Nanba, D., Mori, S., Shiba F., Ishiguro, H., Yoshino, K., Matsuura, N. and Higashiyama, S. ADAM-binding protein Eve-1 is required for ectodomain shedding of EGF receptor ligands. J. Biol. Chem. Vol. 279; 41950-41959, 2004. 245. Toki, F., Nanba, D., Matsuura, N. and Higashiyama, S. Ectodomain shedding of membrane-anchored heparin-binding EGF like growth factor and subcellular localization of the C-terminal fragment in a cell cycle. J. Cell. Physiol. Vol. 202: 839-848, 2005. 246. Shirakata, Y., Kimura, R., Nanba, D., Morimoto, C., Yokota, K., Nakamura, M., Mekada, E., Higashiyama, S., and Hashimoto, K. Heparin-binding EGF-like growth factor is essential for keratinocyte migration in skin wound healing. J. Cell Science Vol. 118: 2363-2370, 2005. 247. Shiraishi, K., Yamasaki, K., Nanba, D., Inoue, H., Hanakawa, Y., Shirakata, Y., Hashimoto, K., and Higashiyama, S. Pbx1is a major target of PLZF-mediated melanoma cell growth suppression. Oncogene Vol. 26: 339-348, 2007. 248. Hirose, T., Ideue, T., Nagai, M., Hagiwara, M., Shu, M-D., Steitz, J.A. A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing. Mol. Cell. Vol. 23, 673-684, 2006. 249. Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, M., Sano, S., Tokunaga, F., Tanaka, K., and Iwai, K. A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J, Vol. 25: 4877-4887, 2006. 250. Hamazaki, J., Iemura, S., Natsume, T., Yashiroda, H., Tanaka, K., and Murata, S. A novel proteasome interacting protein recruits UCH37 to 26S proteasomes. EMBO J, Vol. 25: 4524-4536, 2006. 251. Yamashita JK, Takano M, Hiraoka-Kanie M, Shimazu C, Yan P, Yanagi K, Nakano A, Inoue E, Kita F, Nishikawa SI. Prospective identification of cardiac progenitor potentials by a novel single cell-based cardiomyocyte induction. FASEB J, Vol. 19: 1534-1536, 2005 252. Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of TIE2 signaling in vascular progenitor cells. Blood Vol. 104: 166-169, 2004 253. Huang H, Nakayama Y, Qin K, Yamamoto K, Ando J, Yamashita J, Itoh H, Kanda K, Yaku H, Okamoto Y, Nemoto Y. Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading. J. Artif. Organ Vol. 8: 110-118, 2005 254. Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JK, Obi S, Ohmura N, Matsushita A, Kamiya A, Ando J. Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol, Vol. 288: H1915-1924, 2005 255. Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JK, Ganesan A, Soest van RW, Fusetani N. Azumamides A?E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis. Angew Chem Int Ed, Vol. 45: 7553-7557, 2006 256. Kono T, Kubo H, Shimazu C, Ueda Y, Takahashi M, Yanagi K, Fujita N, Tsuruo T, Wada H, Yamashita JK. Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol, Vol. 26: 2070-2076, 2006 257. Yurugi-Kobayashi T, Itoh H, Schroeder T, Nakano A, Narazaki G, Kita F, Yanagi K, Hiraoka-Kanie M, Inoue E, Ara T, Nagasawa T, Just U, Nakao K, Nishikawa SI, Yamashita JK. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol, Vol. 26: 1977-1984, 2006 258. Hiraoka-Kanie M, Miyagishi M, Yamashita JK. Differentiation stage-specific analysis of gene function with inducible short hair-pin RNA in differentiating embryonic stem cells. Biochem Biophys Res Commun, Vol. 351: 669-674, 2006 　 ▲UP