[Biodynamics] Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics

Strategic Objective

Creation of the technology systems to have absolute control of cells and cell populations by reproducing cell kinetics in silico/in vitro in order to achieve an integrated understanding of life phenomena and realize safe and highly effective treatments among other benefits

Research Supervisor

Tadashi Yamamoto (Professor, Okinawa Institute of Science and Technology (OIST))


Living organisms are in dynamical balance between their responses to environmental stimuli and their ability of maintaining homeostasis. Through observation, experimentation and measurement of biological phenomena conducted by macromolecules including chromosomes, proteins, and lipids at levels of cell-free system, cells and cell populations, the researches of this research area is expected to gain an integrated understanding of dynamical balance of the living organisms in both spatial and temporal dimensions. At the same time, the research of this research area aim to create technologies that can control biological phenomena.
The research should elucidate an operating principle of dynamic and complex biological phenomena that has been hard to address by traditional approaches. To do so, the research needs to utilize rapidly growing high-speed/super-resolution technologies for measurement/analysis, and to integrate life sciences with cutting edge fields of mathematics, physics, chemistry, engineering, information science and computer sciences. We promote leading researches with interdisciplinary views for comprehensive understanding of dynamic systems of the living organisms using modeling and simulation based on mathematical science.

The logo of CREST Biodynamics

Design concept

This round, blue and yellow logo symbolizes the challenges that approximates and expresses the nonlinearity and the hierarchy of a biological dynamics, and consequently, enabling control and design of the regulatory mechanisms of biological phenomena.

Research Area Advisors

Professor, The University of Tokyo

・Kiyoshi ASAI
Professor, The University of Tokyo

Professor, Kwansei Gakuin University

・Tsuyoshi KATO
Professor, Kyoto University

・Takashi SUZUKI
Professor, Osaka University

Professor, Kyoto University

Adjunct professor, Kobe University

・Hiroyoshi TOYOSHIBA
Senior Researcher, FRONTEO, Inc.

・Akihiko NAKANO
Deputy Director, RIKEN Center for Advanced Photonics (RAP)

Advisor, JT Biohistory Research Hall / NPO All About Science Japan

・Kiyoko FUKAMI
Professor, Tokyo University of Pharmacy and Life Sciences

・Hisao HONDA
Adjunct professor, Kobe University

・Masayoshi MISHINA
Professor, Ritsumeikan University

・Yoshikazu YOSHIDA
Corporate Adviser, SHIMADZU Corp.

Year Started : 2012

Elucidation of operating characteristics of the neural circuit based on observational data of the whole nervous system

Research Director:
Yuichi Iino(Professor, The University of Tokyo)

Elucidation and control of dynamics of oscillatory gene expression in cell proliferation and differentiation

Research Director:
Ryoichiro Kageyama(Professor, Kyoto University)

Temporal coding of cellular dynamical system

Research Director:
Sinya Kuroda(Professor, The University of Tokyo)

Controlling cell differentiation with precision through understanding the structure and dynamics of gene regulatory networks

Research Director:
Minoru S.H. Ko(Professor, Keio University)

Investigation of the mechanism of biological pattern formation that may allow us to control the shape of animals

Research Director:
Shigeru Kondo(Professor, Osaka University)

Year Started : 2013

Memory integration process based on cell assembly and neural circuit model

Research Director:
Kaoru Inokuchi(Professor, University of Toyama)

Exploring the principle of tissue organization based on the diversity and heterogeneity of cellular dynamics

Research Director:
Hiroki Kurihara (Professor, The University of Tokyo)

Understanding and Predicting 3D Chromatin Dynamics

Research Director:
Hiroyuki Takeda (Professor, The University of Tokyo)

Elucidation of a novel unified epithelial system defined by the reciprocal regulation of cell-cell adhesion and the apical cytoskeleton and its use for manipulating the epithelial barrier

Research Director:
Sachiko Tsukita (Professor, Osaka University)

Mechanics of generating and sensing flow by cilia

Research Director:
Hiroshi Hamada (Director, RIKEN Center for Developmental Biology)

Solving complex network systems based on theories to connect structure and dynamics

Research Director:
Atsushi Mochizuki (Chief Scientist, RIKEN)

Year Started : 2014

Direct Visualization for RNA Silencing Prcess by Novel Single Molecule Methods : Basis and Appllication

Research Director:
Sotaro Uemura (Professor, Graduate School of Science, The University of Tokyo)

Understanding synapse dynamics through nanoscale structural analyses

Research Director:
Shigeo Okabe (Professor, Graduate School of Medicine, The university of Tokyo)

Chronometabolism: Molecular analysis of biological timing

Research Director:
Hitoshi Okamura (Professor, Graduate School of Pharmaceutical Sciences, Kyoto University)

Spontaneous pattern formation ex vivo

Research Director:
Takashi Miura (Professor, Graduate School of Medical Sciences, Kyushu University)

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