Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies
Strategic Sector
Research Supervisor
Year Started
Outline
This research area aims to elucidate the molecular and cellular mechanisms of the generation, development, and regeneration of the brain neural network; to investigate how neural networks composed of a variety of elements in individual brain areas work and express their specific functions; and to clarify how the brain works as a coherent system by integrating the activities of these local networks. On the basis of such research, it also aims to create technologies for controlling the process of formation and activities of the brain neural network.
Specific approaches may include elucidation of the molecular mechanisms of development, differentiation, regeneration, target recognition, and migration of neurons (components of neural networks) and glial cells that significantly influence neural network formation and functions; elucidation of the mode of neural network activities by combining new technologies, such as visualization of specific neurons with the use of specific expression molecules and fluorescent proteins, simultaneous recording of activities of many neurons, and local stimulation with a caged compound; research to clarify the relationship of higher order brain functions with synaptic events through the combination of research at the network and system levels in model animals and research on the regulatory mechanism of synaptic transmission at the molecular and cellular levels; elucidation of the mechanism of neural network reorganization at the critical period or after brain damage; and creation of technologies for intervention in its process.