Basic Technologies for Controlling Cell Functions Based on Metabolic Regulation Mechanism Analysis

Research Area Website

Strategic Sector

Establishment of Basic Technologies for Controlling of Cell Functions Based on Metabolic Regulation Mechanism Analysis

Research Supervisor

Masahiro Nishijima(President,The Pharmaceutical Society of Japan / Professor,Showa Pharmaceutical University)

Year Started



The area of this research covers studies on new base technologies of cell regulation for the improvement, modification, and addition of cellular functions and for the restoration of disrupted homeostasis by systematic or comprehensive analyses of metabolic changes in cells and by the elucidation of maintenance mechanism of cellular homeostasis. More concretely, it covers studies on the alteration of intracellular states of normal cells in response to external stimuli by various metabolites and their pathological states, the evaluation and classification of cellular states during development, cell modeling and the prediction of functional changes based on available or individual measurement data, and the prediction of compounds and designs of regulatory substances based on the studies that specifically regulate metabolic pathways. In addition, it covers preparation techniques for cells with novel functions based on these studies.

Year Started : 2007

Kazuhiro Iwai
Professor, Osaka University
Susumu Seino
Professor, Kobe University
Masami Yokota Hirai
Team Leader, RIKEN
Masayuki Miura
Professor, The University of Tokyo

Year Started : 2006

Hiroyuki Arai
Professor, The University of Tokyo
Toshiaki Isobe
Professor, Tokyo Metropolitan University
Yo-ichi Nabeshima
President, Institute of Biomedical Research and Innovation, Fundation for Biomedical Research and Innovation
Yukio Fujiki
Professor, Kyusyu University
Tetsuro Mimura
Professor, Kobe University

Year Started : 2005

Yoshiya Oda
President, Eisai Co., Ltd.
Ryo Taguchi
Professor, Chubu University
Atsushi Hirao
Professor, Kanazawa University
Shuichi Yanagisawa
Associate Professor, The University of Tokyo
Mitsuhiro Yanagida
Investigator (Professor extraordinary) , Kyoto University
Minoru Yoshida
Chief Scientist, RIKEN