Research Director

Makoto Murakami

Tokyo Metropolitan Institute of Medical Science
Project leader
website

Outline

Lipid biology has currently been based on studies of individual biosynthetic enzymes or receptors, yet the whole view of lipid-metabolic flows that underlie various diseases still remain incompletely understood. Taking advantages of gene-manipulated mice for a full set of phospholipase A2s as well as downstream enzymes and receptors, in combination with lipidomics, single cell technology and structural biology, this study aims to identify novel lipid-metabolic pathways that are lined to diseases, and thereby to provide rationales for novel therapeutic strategies to control the diseases by targeting the specific lipid pathways.