[Makoto Murakami] PLA2 metabolome-based identification of novel lipid-metabolic maps linked to diseases:from bench to clinic


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Makoto Murakami

Makoto Murakami

Tokyo Metropolitan Institute of Medical Science
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Outline

Lipid biology has currently been based on studies of individual biosynthetic enzymes or receptors, yet the whole view of lipid-metabolic flows that underlie various diseases still remain incompletely understood. Taking advantages of gene-manipulated mice for a full set of phospholipase A2s as well as downstream enzymes and receptors, in combination with lipidomics, single cell technology and structural biology, this study aims to identify novel lipid-metabolic pathways that are lined to diseases, and thereby to provide rationales for novel therapeutic strategies to control the diseases by targeting the specific lipid pathways.

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