[Mikiko Sodeoka] Development of Basic Technology for Identification of Bioactive Metabolites and Target Proteins


Research Director

Mikiko Sodeoka

Mikiko Sodeoka

RIKEN
Chief Scientist
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Outline

We will develop screening system based on synthetic organic chemistry, Raman spectroscopy, and mass spectroscopy. This screening system will use a probe molecule with tiny tag, and the tagged molecules or peptides will be searched from a complex mixture guided by their Raman scattering peaks. Synthetic methods of the probe molecules as well as new chemical methodologies for the screening will be also developed. By using this new system, we will challenge the determination of target protein and binding site of bioactive small molecules as well as identification of unknown metabolites.

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