[Yasuteru Urano] Creation of search techniques for disease-related metabolic activities based on live imaging of clinical specimen and its application to drug developments

Research Director

Yasuteru Urano

Yasuteru Urano

Graduate School of Pharmaceutical Sciences, The University of Tokyo
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In this project, a large chemical library composed of various chemistry-based fluorescence probes will be developed for visualizing metabolic activities of living cells, by fully utilizing our rational molecular design strategies. This fluorescence probe library will be applied to fresh human clinical specimens of cancers and arteriosclerosis to unveil disease-related metabolic activities. Based on the obtained results, novel imaging drugs and tools for ultra-early diagnosis of diseases, as well as novel highly efficient therapeutic drugs with minimal side-effects will be developed, which will realize innovative medical technologies and will facilitate the integration of diagnosis and therapy.

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