Research Director

Hiroki Ueda, M.D., Ph.D.

The University of Tokyo
Professor
website

Outline

The aim of this study is to reveal mechanisms that maintain dynamic homeostasis in the living systems. We choose the mammalian sleep-wake homeostasis as a model system and investigate how the average (diurnality or nocturnality), the dispersion (the length of sleeping time), and the amount (insomniac or hypersomniac responses) of sleep during circadian time are determined by environments and history of activities. For this purpose, we apply developing technologies for organism-level systems biology and execute a comprehensive study to examine dynamic properties of the biological system inside cell-to-tissue scale, and their relations to organism-level phenotypes.