[Tamotsu Yoshimori] Study of Autophagy toward Development of Therapy for Disorders Caused by Hypernutrition


Research Director

Tamotsu Yoshimori

Tamotsu Yoshimori, Ph.D.

Osaka University
Professor
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Outline

Hypernutrition disturbs physiological homeostasis maintained by a coordinated network of endocrine, metabolic, and immune systems, which causes obesity-related diseases including diabetes and elevated risk of infection. The multi-organ network is maintained by autophagy, an intracellular cleaning system and its activity is down or falls short by hypernutrition-caused stresses. In this study, we aim to unravel mechanisms underlying collapse of homeostasis caused by autophagy dysfunction under hypernutrient condition and develop new therapeutic strategy for obesity-caused diseases based on autophagy regulation.


Tamotsu Yoshimori_figure

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