[Makoto Kuro-o] Phosphatostasis and Phosphatopathy: Pathophysiology of the Inter-Organ Network Maintaining Phosphate Homeostasis


Research Director

Makoto Kuro-o

Makoto Kuro-o, M.D., Ph.D.

Jichi Medical University
Professor
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Outline

Phosphate homeostasis is maintained by a balance between dietary intake, urinary excretion, and bone deposition. This process requires inter-organ communication between intestine, kidney and bone mediated by humoral factors like calciprotein particles (CPPs). CPPs are colloidal nanoparticles of calcium phosphate crystals and function as cargos delivering ingested phosphate to the bone. However, CPPs increase upon chronic kidney disease and behave like a pathogen that induces non-infectious inflammation and accelerates aging. The purpose of this project is to understand CPP function in health and disease, which may help identify new diagnostic and therapeutic targets for aging and chronic kidney disease.


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