[Toshimasa Yamauchi] Epigenetic Analysis of the Mechanisms of Metabolic Control and Their Disruption in Type 2 Diabetes and Obesity


Research Director

Toshimasa Yamauchi

Toshimasa Yamauchi

University of Tokyo
Lecturer


Outline

(1) Our research laboratory focuses efforts on the epigenetic analysis of tissues from humans and animals with type 2 diabetes and obesity that result from and become aggravated through interactions between genetic and environmental factors in conjunction with analyses of candidate causal single-nucleotide polymorphisms (SNPs) in genome-wide association studies (GWAS) as a step toward identifying determinants of these diseases and epigenetic changes that result in transcriptional abnormalities in key genes responsible for the diseases;
(2) Our research laboratory also places emphasis on the epigenetic analysis of brown/white adipocytes in their differentiation and re-programming in an attempt to elucidate epigenetic modifications in the determination of their destiny and transformation as well as to identify new principles involved in these mechanisms; and
(3) Our research laboratory also focuses efforts on developing a novel technology that would allow a more convenient, longer-sequencing than is possible with current chromatin interaction analysis (ChIA) which is intended to provide a whole-genome analysis of interactions between regions of protein-DNA interaction that are often far removed in terms of three-dimensional changes in higher-order chromatin structures.
Relevant findings on the epigenetic abnormalities and/or novel mechanisms of onset of disease involved will be brought to bear on the development of a platform technology for the strategic prevention, diagnosis and treatment of type 2 diabetes and obesity.

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