[Yoichi Shinkai] Basic studies aimed for an epigenome-based therapy: proof of concept in brain function


Research Director

Yoichi Shinkai

Yoichi Shinkai

RIKEN
Chief Scientist
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Outline

In this research project, we aim to examine in model mouse 1) how histone lysine methylation is crucial for brain functions and 2) whether the cognition and behavior phenotypes induced by the inactivation of regulating enzyme gene(s) of specific histone lysine methylation can be rescued by the modulation of affected epigenetic mark(s) postnatally. Furthermore, we identify mutation of those regulating enzyme genes in human congenital malformation syndromes and mental disorders. Combination of these studies will provide novel clues for epigenome-based therapy and diagnosis.

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