[Hiroyuki Sasaki] Epigenome analysis of cells in the placenta and endometrium forming the fetal-maternal interface


Research Director

Hiroyuki Sasaki

Hiroyuki Sasaki

Kyushu University
Distinguished Professor and Director
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Outline

This study aims to determine the reference epigenomes of two cell types of the placenta in an early gestational stage and at term and two cell types (one of them in different hormonal phases) of the endometrium. To this end, we will develop and establish necessary technologies. Furthermore, we will determine the epigenomes of cells from placentae of patients with pregnancy induced hypertension, complete hydatidiform moles, and endometriosis specimens and compare them with the reference epigenomes to identify disease-specific changes. We will also study the methylome of sperm from oligospermic patients to improve assisted reproductive technology.

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