Research Project Outline
Cellular proteins are subject to a variety of post-translational modifications. The modifications may constitute dynamic networks to regulate the environmental responses and homeostasis. In particular, protein acetylation and methylation occur in concert with cellular metabolic activity. However, the overall connections between protein modifications and metabolism are still unclear. In this project, we will systematically identify modifications that occur in the fission yeast gene products, and the functional significance of the modifications in the metabolism will be elucidated. Furthermore, we will examine the role of the modifications in the human homologues of the metabolism-related gene products. Finally, we will try to establish the systems for developing inhibitors to control cellular metabolic activity.
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