Analyses of Mechanism underlying Metabolism of Iron and its Prosthetic Groups and Iron-related Disorders

Research Project Outline

Iron is essential nutrient, but it is also toxic to human. Therefore, deregulation of iron metabolism is known to provoke various disorders. Iron is often incorporated into iron-prosthetic groups such as heme and utilized in cells. We have recently shown that cells sense changes in iron availability through iron-prosthetic groups. Moreover, new roles iron plays in the pathogenesis of many disorders have revealed. In this project, we will try to develop new methods for diagnosis as well as treatment for iron-related disorders.

Related Links

• Laboratory Website: http://www.cellbio.med.osaka-u.ac.jp/ (Japanese)