Multi-target Development of RNA-based 'Nanosensors' and 'Modulators'

Research Project Outline

In recent years, research in RNA biology is improving dramatically. New functions and applications of natural and engineered RNA molecules are rapidly being discovered and a bright future for RNA-based technology is expected. In this work, we aim to engineer RNA molecules with strong affinity against a variety of intracellular and extracellular target molecules for two applications. 'RNA sensors' that report the presence or absence of target molecules and 'RNA modulators' that regulate the activity of cellular target molecules will be developed, respectively. The aim of this work is to develop a novel technique to create RNA molecules with new functions for the purpose of analyzing or regulating cellular activity.

Related Links

• Laboratory Website: http://www.ims.u-tokyo.ac.jp/molbiol/index.html (Japanese)