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Past Projects
RNA
ATP
Ultrashort Pulse Laser
Spatio-Temporal
Membrane Mechanisms
Quantum Spin Information
Organ Regeneration
Computational Brain
Nanoscale Quantum Conductor Array
Dynamic Nanomachine
Entropy Control
Calcium Oscillation
Photon Craft
Cell Mechanosensing
Bio-Recycle
Quantum Entanglement
Development of HIV/AIDS vaccine for HIV-1 Subtype-E
Single Molecule Processes
Nanotubulites
Chemotransfiguration
Cold Trapped Ion
Mind Articulation
NeuroGenes
Ceramics Superplasticity
Quantum Transition
Subfemtomole Biorecognition
Supermolecules
Microbial Evolution
Atom Arrangement-Design and Control for New Materials
1992.3~1997.3 Supermolecules Project
Japan-France
Research Directors
Prof. Toyoki Kunitake Prof. Toyoki Kunitake
Dept. of Engineering, Applied Materials, Kyusyu University
Prof. John Osborn   Prof. John Osborn
University of Louis Pasteur

Counterpart Organization: University of Louis Pasteur (France)
Supporting National Agency: Ministere de l'Education Nationale/French National Center for Scientific Research (CNRS)

We conducted studies on primitive biomembranes aiming to elucidate how molecules acquired the ability to self-assemble during the origin of life. Through a cooperative research with France, we intended to build molecular systems advantageous to catalytic responses by bringing the properties of supramolecular structures into the artificial systems.
Systematically synthesizing terpenoid with molecules to reinforce membranes, we defined the self-assembly system and further developed the topography analysis for the structural components of biomembranes. It came to fruition in protoplasts stability with hydrophobic polysaccharide, and the development of substances for membrane fusion, promotion of transferring membrane proteins. Moreover, we achieved pioneering findings: encoded self-assemblies of molecules; chirality selection in self-assembling; creating molecular networks and 2D molecular patterns; molecular recognition of the type of hydrogen bonds at the interface, etc. We expect that those finings will be applied to biotechnologies or medicine and also it is presumed that synthesizing various ultra-thin membranes by alternately stacking layers will have a strong impact upon future material developments.
Japan Science and Technology Agency
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