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| Research
Directors |
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Prof. Yasuyoshi
Watanabe
Osaka Bioscience Institute |
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Prof. Bengt
Langstrom
The Head of PET Center, University
of Uppsala |
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Counterpart Organization: University of Uppsala (Sweden)
Supporting National Agency: Swedish National Board for
Industrial and Technical Development (NUTEK) |
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| Through a collaborative research with Sweden,
by kinetically quantifying extremely small amounts of substances
with the positron-emitting tomography (PET) within subfemtomole
(10-5) range, we intended to define molecular mechanisms
of biological communications with the positron-labeled compounds. |
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| By developing methodology for labeling molecules
with specific positron nuclei (11C, 13N,
76Br, etc.), we produced more than 50 types of
new labeled compounds, leading to the development of a new
evaluation method, “In Vitro PET Method,” which uses a segment
of a living brain. We specified the locations of information
processing for colors, smell, sleep, fever, etc. in the brain,
and found various dopaimine-D2-receptor levels before/after
the treatment of autistic children. Further, we illustrated
that during chronic fatigue syndrome, the ability to intake
acylcarnitine--involved in producing intracellular energy--
decreases in the prefrontal association area of the brain. |
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