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ICORP International Cooperative Research Project  JST Basic Research Program/ICORP Type
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ICORP top page > Past Projects > Subfemtomole Biorecognition Project
Past Projects
Ultrashort Pulse Laser
Membrane Mechanisms
Quantum Spin Information
Organ Regeneration
Computational Brain
Nanoscale Quantum Conductor Array
Dynamic Nanomachine
Entropy Control
Calcium Oscillation
Photon Craft
Cell Mechanosensing
Quantum Entanglement
Development of HIV/AIDS vaccine for HIV-1 Subtype-E
Single Molecule Processes
Cold Trapped Ion
Mind Articulation
Ceramics Superplasticity
Quantum Transition
Subfemtomole Biorecognition
Microbial Evolution
Atom Arrangement-Design and Control for New Materials
1993.1~1997.12 Subfemtomole Biorecognition Project
Research Directors
Prof. Yasuyoshi Watanabe Prof. Yasuyoshi Watanabe
Osaka Bioscience Institute
Prof. Bengt Langstrom   Prof. Bengt Langstrom
The Head of PET Center, University of Uppsala

Counterpart Organization: University of Uppsala (Sweden)
Supporting National Agency: Swedish National Board for Industrial and Technical Development (NUTEK)

Through a collaborative research with Sweden, by kinetically quantifying extremely small amounts of substances with the positron-emitting tomography (PET) within subfemtomole (10-5) range, we intended to define molecular mechanisms of biological communications with the positron-labeled compounds.
By developing methodology for labeling molecules with specific positron nuclei (11C, 13N, 76Br, etc.), we produced more than 50 types of new labeled compounds, leading to the development of a new evaluation method, “In Vitro PET Method,” which uses a segment of a living brain. We specified the locations of information processing for colors, smell, sleep, fever, etc. in the brain, and found various dopaimine-D2-receptor levels before/after the treatment of autistic children. Further, we illustrated that during chronic fatigue syndrome, the ability to intake acylcarnitine--involved in producing intracellular energy-- decreases in the prefrontal association area of the brain.
Japan Science and Technology Agency
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