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Directors |
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Prof.
Kenichi Yoshikawa
Dept. of Physics, Graduate
School of Science, Kyoto University |
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Associate
Prof. Damien Baigl
Ecole Normale Superieure |
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Counterpart Organization: Ecole Normale Superieure (France)
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| Life on the earth maintains their activity by creating spatio-temporal order by itself, as exemplified such as self-development, self-repairing and rhythmicity, through autonomous assembling of rich variety of molecules. Understanding the intrinsic characteristics of life system requires a new methodology to construct real-world models to reproduce the dynamic structure and function of living systems, in addition to the current reductionistic approach. . In this project, we constructed novel experimental systems for reproducing the hierarchical dynamic function of living systems, by combining the "principle of self-organization" (for nanoscale applications) and the "nonlinear system theory" (for larger-scale applications) in a synergetic manner. |
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This project was advanced in cooperation with Ecole Normale Superieure in France, to attain two goals: The first goal was to establish the methodology for causing self-emergence of nanostructures from a single chain of polymeric objects, in which the Japanese side explored the control/design of the phase-transition on the higher-order structure of a longgenomic DNA and the generation of a real-world model equipped with the ability to self-control the genetic function, and the French side advanced the single-molecule technology for charged synthetic macromolecules. The second goal was to construct a real-world model with dynamic function of living systems, in which the Japanese side generated various new autonomous rhythms and molecular motor system driven by chemical energy, and the French side generated nano-to-micro organization by a bottom-up approach. |
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This project aimed at deeper understanding of life phenomena across disciplinary boundaries, and intended to establish fundamental scientific techniques for artificially generating spatio-temporal system with autonomous function through a bottom-up approach. Universal scientific understanding by this project will provide new powerful principle applicable to various fields such as biotechnology, single-molecule engineering, autonomous robot engineering, smart material synthesis, and gene regulation. |
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