|
 |
 |
 |
|
|
| Research
Directors |
|
 |
|
Prof. Joh-E
Ikeda
Dept. of Molecular Neurology, Integrated
Medical Institute, Tokai University |
|
 |
|
Prof. Robert
Korneluk
Dept. of Health Medicine, University
of Ottawa |
|
|
Counterpart Organization: University of Ottawa (Canada)
Supporting National Agency: Canadian Genetic Diseases
Network/Medical Research Council of Canada |
|
|
| Based on the molecular motion and functional
analysis of isolated/identified proteins that are causes of
trinucleotide repeat disorders, representing spinal muscular
atrophy (SMA) and Huntington's Disease (HD), we started a
cooperative research with Canada aimed to define the molecular
mechanisms of selective neuronal apoptosis accompanied with
aging of the brain, the motoneuron systems and diseases. Clarifing
the mechanisms of molecular pathosis in neurodegeneration
leads to developing the way to protect the brain and motoneuron
cells against diseased degeneration, and also keep functional
homeostasis. |
|
| We succeeded in isolating/identifying a candidate
gene of a type-2 amyotrophic lateral sclerosis (ALS2CR6).
The ALS2CR6 contributes not only to understanding the molecular
pathosis and developing the healing techniques, but also finding
further clues for molecular mechanisms of neuronal viability
and homeostasis along with the NAIP, the genes being the cause
of SMA. We could illuminate new aspects toward explicating
the molecular pathosis in neurodegeneration. |
|
