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Past Projects
RNA
ATP
Ultrashort Pulse Laser
Spatio-Temporal
Membrane Mechanisms
Quantum Spin Information
Organ Regeneration
Computational Brain
Nanoscale Quantum Conductor Array
Dynamic Nanomachine
Entropy Control
Calcium Oscillation
Photon Craft
Cell Mechanosensing
Bio-Recycle
Quantum Entanglement
Development of HIV/AIDS vaccine for HIV-1 Subtype-E
Single Molecule Processes
Nanotubulites
Chemotransfiguration
Cold Trapped Ion
Mind Articulation
NeuroGenes
Ceramics Superplasticity
Quantum Transition
Subfemtomole Biorecognition
Supermolecules
Microbial Evolution
Atom Arrangement-Design and Control for New Materials
2000.1~2004.12 Cell Mechanosensing Project
Japan-U.S.A.
Research Directors
Prof. Masahiro Sokabe Prof. Masahiro Sokabe
Graduate School of Medicine, Nagoya University
Prof. Frederick Sachs   Prof. Frederick Sachs
Dept. of Physiology and Biophysical Sciences, State University of New York at Buffalo

Counterpart Organization: State University of New York (U.S.A)

Virtually every cell can respond to mechanical stimuli. Not only specialized mechanosensory cells like those in the inner ear and skin but ordinary non-sensory cells respond to external mechanical stimuli. In addition cells also react to diverse forces generated in the cell accompanied with its growth, division, morphogenesis, and movement. We named these capabilities of the cell "Cell Mechanosensing".
In this cooperative research, MS channel genes from myocardia have been identified. And it has been found that a natural peptide(GsMtx-4) from spider venom works as an MS channel specific blocker. Also we found that the mechanosensing machinery of higher animals is not constituted of a simple MS channel but a supra-molecular complex composed of MS channel and cytoskeleton.

Through this research cooperated with State University of New York, Japanese side have proceeded molecular and cell biological approaches while American side biophysical and biochemical approaches to investigate the mechanism of Cell Mechanosensing. The achievements must give immeasurable impacts upon basic biology, clinical medicine, space medicine, agriculture, and so on. In addition, it is expected that the discovery of MS channel specific blockers leads to the development of new medicines that would suppress atrial fibrillation inviting cerebral infraction.

Japan Science and Technology Agency
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