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ICORP International Cooperative Research Project  JST Basic Research Program/ICORP Type
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ICORP top page > Past Projects > Calcium Oscillation Project
Past Projects
Ultrashort Pulse Laser
Membrane Mechanisms
Quantum Spin Information
Organ Regeneration
Computational Brain
Nanoscale Quantum Conductor Array
Dynamic Nanomachine
Entropy Control
Calcium Oscillation
Photon Craft
Cell Mechanosensing
Quantum Entanglement
Development of HIV/AIDS vaccine for HIV-1 Subtype-E
Single Molecule Processes
Cold Trapped Ion
Mind Articulation
Ceramics Superplasticity
Quantum Transition
Subfemtomole Biorecognition
Microbial Evolution
Atom Arrangement-Design and Control for New Materials
2001.1~2005.12 Calcium Oscillation Project
Research Directors
Prof. Katsuhiko Mikoshiba Prof. Katsuhiko Mikoshiba
The Institute of Medical Science, The University of Tokyo/Group Director, RIKEN Brain Science Institute
Prof. Anita Aperia   Prof. Anita Aperia
Karolinska Institute

Counterpart Organization: Karolinska Institute (Sweden)

Calucium is a component of bone as a skeleton, and ionized calcium --- calcium ion (Ca2+) --- conducts a variety of physiological work. When the cell is stimulated, intracellular Ca2+ concentration slowly oscillates; this phenomenon is called, "Ca2+ oscillation."
The aim of this project has been the clarification of the Ca2+ oscillation mechanism and its functions with focus on IP3 receptors which are known as intracellular Ca2+ release channels located on the endoplasmic reticulum. This project succeeded in determining the protein conformation of IP3 receptors and discovering the new protein molecules (IRBIT, CARP, and Erp44) that regulate the IP3 receptors' function, and elucidated the fact that IP3 receptors are crucially related not only to the embryonic development of a frog, which determines the would-be stomach part and dorsal part, but also to the exocrine system of mice.

In this collaborative research with Karolinska Institute, Japanese side put emphasis on the normality based on basic science, while Sweden side mainly concentrated on the abnormality (diseases) from the viewpoint of clinical science. The achievements must contribute to the understanding of basic mechanism --- transcription of genes, immunological system, endocrine and exocrine system, and neural transmission (signal transduction) --- and the development of therapeutic drugs to cure the pathogenetic situation of Ca2+ signaling.

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